Evidence map›Paper›PMID 41068958›Full record

ArticleActa neuropathologica communications2025

White adipose tissue undergoes pathological dysfunction in the TDP-43

Cristina Benito-Casado, Esther Durán-Mateos, Águeda Ferrer-Donato, Gemma Barroso García, Raúl Domínguez-Rubio, Mónica Povedano, Carmen M Fernandez-Martos

Abstract read
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cristina Benito-CasadoDepartment of Health and Pharmaceutical Sciences, School of Pharmacy, Universidad CEU-San Pablo, Urbanización Monteprincipe, Boadilla del Monte, 28660, Madrid, Spain.
Esther Durán-MateosDepartment of Basic Medical Sciences, School of Medicine, Universidad CEU-San Pablo, Madrid, Spain.
Águeda Ferrer-DonatoDepartment of Health and Pharmaceutical Sciences, School of Pharmacy, Universidad CEU-San Pablo, Urbanización Monteprincipe, Boadilla del Monte, 28660, Madrid, Spain.
Gemma Barroso GarcíaSESCAM, SAI-Proteómica, Hospital Nacional de Parapléjicos, SAI-HNP-IDISCAM, Toledo, Spain.
Raúl Domínguez-RubioFunctional Motorneuron Unit (UFMN), Service of Neurology, Bellvitge University Hospital, Hospitalet de Llobregat, Spain.
Mónica PovedanoFunctional Motorneuron Unit (UFMN), Service of Neurology, Bellvitge University Hospital, Hospitalet de Llobregat, Spain.
Carmen M Fernandez-MartosDepartment of Health and Pharmaceutical Sciences, School of Pharmacy, Universidad CEU-San Pablo, Urbanización Monteprincipe, Boadilla del Monte, 28660, Madrid, Spain. Carmen.fernandezmartos@ceu.es.

Funding

"la Caixa" Banking Foundation and co-funded by Fundación Luzón LCF/PR/HR19/52160016
6 · The paper itself

Abstract

White adipose tissue (WAT) has a crucial role in maintaining systemic energy homeostasis. Numerous biological pathway studies have highlighted the importance of adipokines in regulating metabolic pathways and contributing to metabolic dysfunction in animal models and patients with ALS. Despite these associations, the specific molecular mechanisms remain poorly understood. Moreover, the direct contribution of WAT to the energy metabolism abnormalities observed in ALS has yet to be clearly defined. The current study sought to identify perturbances in WAT, main source of leptin, during the clinical course of the disease in TDP-43

Indexed as

Adipose Tissue, WhiteAmyotrophic Lateral SclerosisDNA-Binding ProteinsAgedAnimalsDisease Models, AnimalFemaleHumansLeptinMaleMiceMice, Inbred C57BLMice, TransgenicMiddle AgedObesityDNA-Binding ProteinsLeptinTardbp protein, mouseAmyotrophic lateral sclerosis (ALS)Sporadic ALSTAR DNA binding protein (TDP-43)White adipose tissue (WAT)

Identifiers

PMID41068958
PMCPMC12512303

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.