ArticleCurrent developments in nutrition2025
Comparing Mediterranean and Western Diets: Cognitive and Microbiota Effects in Middle-Aged Rats.
Article in Current developments in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gut Microbiome-Hormone Interactions and Precision Fermentation in the Prevention of Early Cardiovascular Risk in Adolescents.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As the global population continues to age, cognitive decline has emerged as a major area of concern. Modifiable lifestyle factors, such as diet, have been associated with the trajectory of brain aging. Dietary patterns such as the Western diet (WD) have been linked to cognitive decline, whereas a Mediterranean diet (MeDi) promotes healthy brain aging. Objectives: This study aimed to compare the effects of MeDi and WD on gut microbiota and cognitive health in middle-aged rats. Our hypothesis was that the MeDi, when introduced to middle-aged rats, would maintain cognitive health and produce a distinct gut microbiota composition relative to a WD. Methods: Twelve-month-old male Fischer344 rats were randomly assigned to MeDi, WD, or chow ( Results: There were trending differences in cognitive function in MeDi rats relative to WD rats. Rats exhibited distinct diet-dependent microbial phenotypes with 28 differentially abundant bacteria, including Conclusions: A longer diet duration may be needed to elicit robust differences in cognitive function driven by the changes in microbiota and neurobiology. This study highlights that a short-term diet introduced in middle age has trending effects on cognitive performance but significantly impacts gut microbiota composition and gene expression of biomarkers of brain health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.