Evidence map›Paper›PMID 41069424›Full record

ArticleBrain communications2025

Biallelic

Francesca Magrinelli, Lucie S Taylor, Sahar Sedighzadeh, Dalila Moualek, Mariasavina Severino, Daniel N Grba, Charlotte L Alston, Michael Champion, Ali Reza Tavasoli, Karine Lascelles and 18 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bypass Treatments for Primary Coenzyme Q10 Deficiency: An Update.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Francesca MagrinelliDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.ORCID https://orcid.org/0000-0003-4706-6245
Lucie S TaylorMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.
Sahar SedighzadehDepartment of Biological Science, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran.
Dalila MoualekService de Neurologie, CHU Mustapha Bacha, Alger 16000, Algeria.
Mariasavina SeverinoNeuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genova 16147, Italy.ORCID https://orcid.org/0000-0003-4730-5322
Daniel N GrbaMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, United Kingdom.ORCID https://orcid.org/0000-0003-2915-951X
Charlotte L AlstonMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.
Michael ChampionDepartment of Paediatric Inherited Metabolic Disease, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, United Kingdom.
Ali Reza TavasoliDepartment of Neurology, Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85016, USA.
Karine LascellesChildren's Neuroscience Centre, Evelina London Children's Hospital, Guy's and St Thomas' NHS Trust, London SE1 7EH, United Kingdom.
Vykuntaraju K GowdaDepartment of Pediatric Neurology, Indira Gandhi Institute of Child Health, Near NIMHANS, Bengaluru, Karnataka 560029, India.ORCID https://orcid.org/0000-0001-7244-0492
Varunvenkat M SrinivasanDepartment of Pediatric Neurology, Indira Gandhi Institute of Child Health, Near NIMHANS, Bengaluru, Karnataka 560029, India.
Sahand Tehrani FatehSchool of Medicine, Tehran University of Medical Sciences (TUMS), Tehran 1416634793, Iran.
Mohammad Kordi-TamandaniDepartment of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan 9816745785, Iran.
Ali KhajehChildren and Adolescent Health Research Center, School of Medicine, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.
Saeedeh YaghoubiDepartment of Pediatrics, School of Medicine, Children and Adolescents Health Research Center, Research Institute of Cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.
Natalia DominikDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom.
Meisam BabaeiDepartment of Pediatrics, North Khorasan University of Medical Science, Bojnourd 9417694735, Iran.
Mohsen JavadzadehDepartment of Pediatric Neurology, Shahid Beheshti University of Medical Sciences, Tehran 1983969367, Iran.
Jamileh Rezazadeh VaraghchiHasti Genetic Counseling Center of Welfare Organization of Southern Khorasan, Birjand 9719866879, Iran.
Mohammad MiryounesiCenter for Comprehensive Genetic Services, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.
Ehsan Ghayoor KarimianiDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom.
Meriem TazirService de Neurologie, CHU Mustapha Bacha, Alger 16000, Algeria.
Lamia Ali PachaService de Neurologie, CHU Mustapha Bacha, Alger 16000, Algeria.
Kailash P BhatiaDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
Robert W TaylorMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.
Henry HouldenDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom.ORCID https://orcid.org/0000-0002-2866-7777
Reza MaroofianDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom.ORCID https://orcid.org/0000-0001-6763-1542

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biallelic

Indexed as

lactic acidosisLeigh syndromemutational hotspotseizuresspasticity

Identifiers

PMID41069424
PMCPMC12507085

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.