ArticleJournal of oral microbiology2025
Antifungal efficacy of caffeic acid and nano-caffeic acid particles against candidiasis: an
Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Investigating the effectiveness of N-acetyl cysteine mouthwash in preventing chemotherapy-induced oral mucositis: a randomized, double-blind controlled trial.BMC oral health · 2026Trial
- Caffeic Acid and Human Health: Evidence-Based Roles in Disease Prevention and Treatment.International journal of molecular sciences · 2026Review
- Antioxidant properties of nano-formulated carotenoids and natural phenolic compounds against oxidative stress-induced health diseases.Open research Europe · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Candidiasis is the most common oral fungal infection. Several medications have been introduced to manage this infection. This study investigated the antifungal effect of caffeic acid and nano-caffeic acid. Materials and methods: The size and particle dispersion index (PDI) of caffeic acid-containing niosome vesicles were measured after their production. The zeta potential was measured using a Zetasizer Nano ZS, and the amount of nano-caffeic acid released from the vesicles was measured. Results: The optimal formulation had 100 mg Tween 60, 100 mg Span 60, 200 mg cholesterol, a size of 271.83 ± 3.11 nm, a PDI of 0.21 ± 0.02, a zeta potential of 5.58 ± 0.47 mV and an encapsulation efficiency (EE%) of 42.34 ± 4.34%. The size, absolute zeta potential and EE% increased significantly with increasing cholesterol content from zero to 200 mg ( Conclusion: According to the MIC
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.