SynthesisFrontiers in public health2025
Association between night shift work and cardiovascular disease: a systematic review and dose-response meta-analysis.
Synthesis in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Dietary Behavior, Physical Activity, and 24-Hour Rhythm Coherence: A Digital Phenotyping Perspective on Vascular and Glycemic Health.Nutrients · 2026Review
- Dietary pattern and night work: metabolic syndrome in healthcare workers.Archives of endocrinology and metabolism · 2026Article
- Cardiovascular Risk and Modifiable Risk Factors in Shift-Working Healthcare Workers: A Gender-Stratified Cross-Sectional Study.Journal of clinical medicine · 2026Article
- The effect of night shift work on daytime sleepiness and physiological health among pediatric nurses in Northern Ghana: a cross-sectional survey.Scientific reports · 2026Article
- Article
- Gut Microbiota Diversity and Composition Across Shift Types and the Effects of Walnut Supplementation-An Observational and Interventional Study.International journal of environmental research and public health · 2026Observational
- Occupational stress, cardiovascular vulnerability and sudden cardiac death in police officers: mechanisms and the protective role of structured exercise.Frontiers in public health · 2026Review
- The association between shift work, occupational physical activity and cardiovascular-kidney-metabolic syndrome: a cohort study in China.Frontiers in public health · 2026Article
- Health Implications of Shift Work in Airline Pilots and Cabin Crew: A Narrative Review and Pilot Study Findings.Nutrients · 2025Review
- Metabolic risk stratification of night shift workers in a large retail workplace through clustering and SHAP interpretation.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Shift work, particularly night shift work, has become increasingly prevalent on a global scale and is associated with multiple health issues including type 2 diabetes and cardiovascular diseases (CVD). This study aimed to assess the relationship between night shift work and the incidence and mortality of CVD. Method: Six electronic databases including PubMed, Embase, Cochrane Library, Web of Science, CINAHL, and Scopus were searched from inception until August 10, 2025. Cohort studies eligible for inclusion addressed the association between night shift work and outcomes of CVD. STATA 18.0 software was used for meta-analysis. The dose-response relationship was estimated using generalized least squares regression, and restricted cubic splines were used to analyze potential linear or nonlinear associations. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of the studies. Quality assessment and data extraction were performed independently by two researchers. Results: Twenty-three cohort studies were included. Overall, this meta-analysis revealed that night shift work significantly increased the risk of total CVD events (RR = 1.13, 95% CI = 1.10-1.16) and total CVD mortality (RR = 1.27, 95%CI = 1.18-1.36). Dose-response analysis indicated that each 5-year increment in shift work duration was associated with a 7% higher risk of CVD incidence (RR = 1.07, 95% CI: 1.04-1.09) and a 4% increased risk of CVD mortality (RR = 1.05, 95% CI: 1.03-1.06). Subgroup analyses identified elevated risks for incident coronary heart disease (CHD) (RR = 1.22, 95% CI = 1.16-1.28) and ischemic heart disease (IHD) (RR = 1.09, 95% CI = 1.05-1.14), but not stroke (RR = 1.06, 95% CI = 0.95-1.18), and night shift work was associated with an increased risk of mortality due to CHD (RR = 1.22, 95% CI = 1.10-1.36), IHD (RR = 1.39, 95% CI = 1.06-1.84), and stroke (RR = 1.49, 95% CI = 1.04-2.12). Conclusion: These findings indicate that night shift work is significantly associated with increased CVD incidence and mortality risk, highlighting the need for targeted prevention strategies. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251060086. CRD: 420251060086.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.