Myo-inositol supplementation in gestational diabetes mellitus: is there any interference with diet?

Background/objectives: Gestational Diabetes Mellitus (GDM) affects 31.6% of pregnant women in Qatar. Myo-inositol (MI) supplementation has been proposed to reduce GDM risk, but its interaction with diet and lifestyle remains unclear. This study assessed the effects of physical activity and diet on MI supplementation and GDM onset throughout pregnancy. Subjects/methods: A randomized double-blind clinical trial was conducted at Sidra Medicine hospital, involving pregnant women assigned to either the MI ( Results: Dietary adjustments during pregnancy included increased protein and fiber intake, reduced salt, and higher consumption of simple sugars. The MI group showed higher physical activity (walking time/week), lower weight gain, and increased fiber intake (beans and tubers) compared to PLA, which consumed more high-fat, high-sugar foods. Despite these differences, no major differences in GDM incidence were observed between groups. Conclusion: MI supplementation was associated with a healthier diet and higher physical activity. Findings suggest that an active lifestyle and balanced diet may enhance MI's efficacy in lowering GDM risk. Further research is needed to clarify this relationship. Clinical trial registration: The study Clinical trial registration ID is ISRCTN Registration number ISRCTN16448440.