Trial reportJournal of oral & facial pain and headache2025
Comparison of the efficacy of connective tissue massage and manual lymphatic drainage in patients with migraine: a randomized controlled trial.
Trial report in Journal of oral & facial pain and headache, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05976399 (The Investigation of The Effectiveness Of Manual Lymph Drainage in Individuals With Migraine), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Investigation of The Effectiveness Of Manual Lymph Drainage in Individuals With Migraine
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate and compare the effects of connective tissue massage (CTM) and manual lymphatic drainage (MLD) on neck pain, disability, quality of life, and pain thresholds in patients with migraine.
methodsA total of 40 migraine patients were randomly assigned to either the CTM or MLD group. Quality of life was assessed using the Short Form-36 (SF-36); pain sensitivity and perception were measured using an algometer, and neck pain was evaluated using the Neck Pain and Disability Scale (NPAD). Patients tracked their headaches in a pain diary for 15 days before and after the intervention. Both groups received 45 min of treatment twice a week for six weeks.
resultsAfter treatment, the pain threshold increased significantly, whereas total medication use and the number of pain days decreased in both groups. However, while CTM led to a greater reduction in NPAD scores (
conclusionsThese findings suggest that CTM and MLD can help migraine patients, with MLD showing a stronger effect on pain relief and well-being, whereas CTM being more effective in reducing neck pain and disability. CLINICAL
trial registrationClinicalTrials.gov/NCT05976399.
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