ArticleNature communications2025
A model for membrane curvature generation by caveolin discs driven by differential contact interaction.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Membrane Curvature Generation by the Caveolin 8S Complex and the Role of Cholesterol.Journal of chemical theory and computation · 2026Article
- Caveolae mechanics in cellular functions and disease.Nature reviews. Molecular cell biology · 2026Review
- Membrane remodeling by the collective action of caveolin-1.Nature communications · 2026Article
- Phosphorylation-dependent structure and dynamics of caveolin-1 8S complex.Biophysical journal · 2026Article
- A lipid-centric view of endocytosis by caveolae.Nature cell biology · 2026Review
- Membrane Curvature Generation by the Caveolin 8S Complex and the Role of Cholesterol.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The recent discovery of the flat, disc-like structure of caveolin oligomers, predicted to be embedded in one membrane leaflet, has challenged earlier models of membrane curvature generation by caveolins during caveola biogenesis. Here, we provide a mechanism for this phenomenon. We propose that the central factor behind the membrane shaping by caveolin discs is a difference in interaction energies of the membrane leaflets with each other and with the hydrophobic faces of the caveolin discs. We demonstrate, through computational analysis, that the caveolin disc embedding induces elastic stresses of tilt and splay in the membrane leaflets, which, in turn, drive membrane kinking along the disc boundaries. The predicted resulting membrane shapes have an overall curved and faceted appearance in agreement with observations. Our model also provides a mechanistic understanding of the role of the negative intrinsic curvatures of lipids such as cholesterol and diacylglycerols, in caveola assembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.