Evidence map›Paper›PMID 41074484›Full record

ArticleRevista de neurologia2025

[West Nile Virus Neuroinvasive Disease: A Retrospective Analysis of Hospitalized Cases in a Tertiary Care Center in Southern Europe].

Antonio Cristóbal Luque-Ambrosiani, Ignacio Lopera-Rodríguez, Alicia Fernández-Panadero, María Del Sol Torralbo-Gómez, Mikel Salgado-Irazabal, Francisco José Hernández-Chamorro, Francisco José Hernández-Ramos, María Dolores Jiménez-Hernández, Alfredo Palomino-García

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista de neurologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonio Cristóbal Luque-AmbrosianiNeurology Unit, Virgen del Rocío University Hospital, 41013 Seville, Spain.
Ignacio Lopera-RodríguezNeurology Unit, Virgen del Rocío University Hospital, 41013 Seville, Spain.
Alicia Fernández-PanaderoNeurology Unit, Virgen del Rocío University Hospital, 41013 Seville, Spain.
María Del Sol Torralbo-GómezPediatrics Unit, Virgen del Rocío University Hospital, 41013 Seville, Spain.
Mikel Salgado-IrazabalNeurology Unit, Virgen del Rocío University Hospital, 41013 Seville, Spain.
Francisco José Hernández-ChamorroNeurology Unit, Virgen del Rocío University Hospital, 41013 Seville, Spain.
Francisco José Hernández-RamosNeurology Unit, Virgen del Rocío University Hospital, 41013 Seville, Spain.
María Dolores Jiménez-HernándezNeurology Unit, Quirónsalud Sagrado Corazón Hospital, 41013 Seville, Spain.
Alfredo Palomino-GarcíaNeurology Unit, Virgen del Rocío University Hospital, 41013 Seville, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWest Nile virus (WNV) is a flavivirus primarily transmitted by mosquitoes of the

methodsPatients with neurological symptoms and confirmed WNV infection through serology and/or detection in urine and/or cerebrospinal fluid (CSF) between 2017 and 2023 were included. Data on demographics, medical history, symptoms, diagnostic workup, treatment, and prognosis at discharge, 12 months, and 24 months were analyzed. Patients were categorized based on whether they required intensive care unit (ICU) admission, CSF biochemistry, and treatment employed, among other factors.

resultsForty patients with a median age of 65 years (45% female) were included; 8% were immunosuppressed. Fever was present in 95%, and 85% experienced prodromal symptoms. Altered consciousness (73%) was the most common neurological symptom. ICU admission was required in 33% of cases, and mechanical ventilation in 25%. In-hospital mortality was 15%. At 24 months, 48% maintained good functional status, with a median follow-up of 35 months. Diagnostic and therapeutic interventions did not influence prognosis.

conclusionsAlthough neuroinvasive WNV disease is rare, it carries significant morbidity and mortality, with no specific therapeutic measures impacting outcomes. Prioritizing efforts to control infection spread is critical.

Indexed as

West Nile FeverAdultAgedAged, 80 and overEuropeFemaleHospitalizationHumansMaleMiddle AgedRetrospective StudiesTertiary Care CentersWest Nile viruscritical carefunctional statushospital mortalityprognosisWest Nile virus

Identifiers

PMID41074484
PMCPMC12516826

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.