ArticleJournal of materials science. Materials in medicine2025
Functionalized bacterial cellulose membranes with controlled biodegradation and β-estradiol delivery properties for potential intrauterine adhesion prevention.
Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Intrauterine adhesions pose a significant challenge to female fertility, with current treatments showing limited efficacy and safety concerns, including poor biocompatibility and secondary trauma risks. In this work, we present a novel biodegradable bacterial nanocellulose (BC)-based physical barrier that integrates controlled drug release capabilities for preventing intrauterine adhesions. Through TEMPO-mediated oxidation and N-vinyl pyrrolidone grafting, we developed BC membranes exhibiting superior biocompatibility (cell death rate <5%) and selective fibroblast inhibition. The system achieves controlled biodegradation over 14 days while maintaining mechanical integrity (tensile strength >2.0 MPa) and providing sustained β-estradiol release. This approach represents a significant advancement in intrauterine adhesion prevention strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.