Evidence map›Paper›PMID 41075070›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2025

The association between enlarged perivascular spaces and muscle sympathetic nerve activity in normotensive and hypertensive humans.

Donggyu Rim, William Pham, Rania Fatouleh, Annemarie Hennessy, Markus Schlaich, Luke A Henderson, Vaughan G Macefield

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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Donggyu RimDepartment of Neuroscience, Monash University, Level 6, 99 Commercial Road, Melbourne, VIC, 3004, Australia. donggyu.rim@monash.edu.ORCID http://orcid.org/0000-0002-0974-6752
William PhamDepartment of Neuroscience, Monash University, Level 6, 99 Commercial Road, Melbourne, VIC, 3004, Australia.
Rania FatoulehFaculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Annemarie HennessyFaculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Markus SchlaichDobney Hypertension Centre, Medical School - Royal Perth Hospital Unit and RPH Research Foundation, University of Western Australia, Perth, WA, Australia.
Luke A HendersonFaculty of Medicine and Health, School of Medical Sciences (Neuroscience), Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Vaughan G MacefieldDepartment of Neuroscience, Monash University, Level 6, 99 Commercial Road, Melbourne, VIC, 3004, Australia.

Funding

National Health and Medical Research Council of Australia GTN1007557National Health and Medical Research Council of Australia GTN1100042
6 · The paper itself

Abstract

purposeHypertension is characterised by both enlarged perivascular spaces (ePVS) and chronically elevated resting sympathetic outflow. ePVS is associated with heart rate variability, suggesting links to autonomic outflow; however, heart rate variability offers limited information on sympathetic nerve activity. Here, we assessed whether ePVS are associated with muscle sympathetic nerve activity (MSNA) in 25 hypertensive patients and 50 healthy normotensive adults.

methodsT1-weighted MRI anatomical brain images were analysed for ePVS using a deep learning-based segmentation algorithm (nnU-Net). Spontaneous bursts of MSNA were recorded from the right common peroneal nerve via a tungsten microelectrode immediately before the MRI scan in a supine position. A backward regression analysis was conducted to test the relationship between ePVS and MSNA.

resultsSignificant associations were found between MSNA and ePVS in the white matter (β = 1.02, p = 0.007), basal ganglia (β = 0.43, p = 0.001), and hippocampus (β = 0.24, p = 0.010) in healthy normotensive adults. Similar associations were observed in individuals with hypertension. Notably, the association between MSNA and midbrain ePVS cluster was only observed in the hypertensive group (β = 0.41, p = 0.005).

conclusionePVS were associated with MSNA in both normotensive and hypertensive patients. These findings warrant further research into the causal relationship between MSNA and ePVS and highlight the potential for ePVS as a neuroimaging biomarker for sympathetic nerve activity.

Indexed as

Glymphatic SystemHypertensionMuscle, SkeletalSympathetic Nervous SystemAdultAgedBlood PressureFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedGlymphaticMagnetic resonance imagingMuscle sympathetic nerve activityPerivascular spaces

Identifiers

PMID41075070
PMCPMC12664836

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.