Evidence map›Paper›PMID 41077430›Full record

ReviewThe Surgical clinics of North America2025

The Role of the Microbiome and the Neurovascular Unit.

Sean P Polster

Abstract readReview
In one paragraph

Review in The Surgical clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Sean P PolsterDepartment of Neurological Surgery, University of Chicago, 5841 South Maryland Avenue MC3026, Chicago, IL 60637, USA. Electronic address: spolster@uchicago.edu.

Funding

Neurosurgeon Research Career Development Program (NRCDP)K12NS129164 · NINDS · WASHINGTON UNIVERSITY · PI Sepideh Amin-Hanjani, Emad N Eskandar · 2023 to 2026
$6.7M
NINDS NIH HHS K12 NS129164
6 · The paper itself

Abstract

The gut-brain axis plays a crucial role in neurovascular diseases, linking gut microbiota to blood-brain barrier integrity, neuroinflammation, and disease progression. Conditions such as cerebral cavernous malformations, traumatic brain injury, radiation-induced damage, and stroke exhibit microbiome-driven modulation that may be relevant to explain disease variance. Microbial metabolites have been shown to influence endothelial function and secondary brain injury mechanisms. Emerging interventions of dietary modifications, probiotics, fecal microbiota transplantation, and metabolite-based therapies show promise in mitigating neurovascular damage. Future research should focus on microbiome-targeted treatments, biomarker discovery, and personalized strategies to optimize neurovascular health through gut microbiome modulation.

Indexed as

Blood-Brain BarrierGastrointestinal MicrobiomeFecal Microbiota TransplantationHumansProbioticsCerebral cavernous malformationsGut-brain axisMicrobiomeNeurosurgeryNeurovascular unitRadiation damageStrokeTraumatic brain injury

Identifiers

PMID41077430
PMCPMC13472747

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.