SynthesisNeonatology2026
Early Electroencephalography and Amplitude-Integrated Electroencephalography for the Prediction of Neurodevelopmental Outcomes in Neonates with Hypoxic Ischemic Encephalopathy: A Systematic Review and Diagnostic Test Accuracy Meta-Analysis.
Synthesis in Neonatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionElectroencephalography (EEG), including both conventional EEG (cEEG) and amplitude-integrated EEG, is early prognostic tools utilized in neonates with hypoxic ischemic encephalopathy (HIE). However, the reported predictive accuracy of EEG varies widely.
methodsWe evaluate the diagnostic accuracy of EEG in predicting neurodevelopment impairment (NDI) among neonates ≥35 weeks with any stage HIE. MEDLINE, Embase, Cochrane Library, and Scopus were searched from inception until 24th December 2024. Observational studies evaluating EEG performed in the first 72 h of life in neonates with HIE, and reporting NDI outcomes assessed after 12 months were included. Two authors independently extracted data. A Bayesian random-effects bivariate model was used for diagnostic test accuracy meta-analysis. Risk of bias was assessed using QUADAS-2, and certainty of evidence (CoE) with GRADE. NDI defined as cognitive/motor scores <1 SD below the mean or presence of motor disability.
resultsSixty-two studies (n = 3,929) were included. In neonates who underwent therapeutic hypothermia (TH) (34 studies, n = 2,538), EEG showed a sensitivity of 88.3% (95% credible interval [CrI]: 83.7%, 92.8%) and specificity of 63.9% (53.6%, 72.8%). In no TH group (33 studies, n = 1,391), the sensitivity was 87.2% (77.5%, 93.5%) and specificity was 76.3% (61.5%, 86.8%). Further, in neonates who received TH (12 studies, n = 868), cEEG had an acceptable sensitivity of 84.1% (77.3%, 89.9%) and specificity of 76.7% (66.9%, 84.3%). CoE being predominantly moderate.
conclusionEEG has good sensitivity in predicting NDI regardless of TH status and may aid in identifying high-risk neonates for further evaluation.
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