Evidence map›Paper›PMID 41078867›Full record

ArticleBioactive materials2026

Spermidine reduces peri-implant inflammation and fibrosis to nurture osseointegration.

Qiming Liu, Qianqian Wu, Tingting Cao, Rundong Miao, Chenyu Wang, Jiawei Zhang, Xue Gao, Li Wang, Guoxin Shi, Jinyu Lai and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Qiming LiuSchool of Materials Science and Engineering, Jilin University, Changchun, 130022, China.
Qianqian WuDepartment of Burn Surgery, The First Hospital of Jilin University, Jilin University, Changchun, 130061, China.
Tingting CaoDepartment of Gastroenterology, The First Hospital of Jilin University, Jilin University, Changchun, 130021, China.
Rundong MiaoKey Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.
Chenyu WangDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Jilin University, Changchun, 130021, China.
Jiawei ZhangKey Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.
Xue GaoDepartment of Orthopedics, The Second Hospital of Jilin University, Jilin University, Changchun, 130022, China.
Li WangDepartment of Orthopedic, Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Guoxin ShiKey Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.
Jinyu LaiKey Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.
Runjiao YangKey Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.
Xianshu PiaoKey Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.
Jiaao YuDepartment of Burn Surgery, The First Hospital of Jilin University, Jilin University, Changchun, 130061, China.
Jincheng WangDepartment of Orthopedics, The Second Hospital of Jilin University, Jilin University, Changchun, 130022, China.
Song LiangKey Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.
Shuqing KouSchool of Materials Science and Engineering, Jilin University, Changchun, 130022, China.
Thomas M RobertsDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Bingdi WangKey Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.
Zhenning LiuKey Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun, 130022, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medical implants of exogenous materials often induce foreign body response (FBR) in hosts, which is characterized by inflammation and fibrosis. Herein, composite scaffolds with interpenetrating hard and soft phases were fabricated, consisting of titanium alloy and a biomatrix mimicking extracellular matrix. Spermidine-functionalized biomatrix (CST@GOA) not only inhibits inflammatory response and osteoclastogenesis of macrophages, but also fosters migration and osteogenesis of MC3T3-E1 cells. Interestingly, CST@GOA can mitigate acute inflammation and fibrosis, characteristics of FBR, against silicone implanted in rats. Moreover, bone repair experiments in rabbits show that CST@GOA-interpenetrated porous titanium alloy scaffolds attenuate FBR against metal implants and promote osseointegration. Meanwhile, diethylenetriamine, a polyamine resembling spermidine in chemistry, has been used in place of spermidine to enable 'operando' comparison in both cell and animal experiments. Proteomic analysis of rabbit bone tissues reveals that spermidine modulates PI3K-Akt pathway by upregulating PTEN, which may play a pivotal role in coordinating downstream signaling of inflammation, autophagy and bone homeostasis. Together, it is demonstrated that spermidine can endow either synthetic polymers or metal implants with

Indexed as

FibrosisForeign body response (FBR)InflammationMedical implantsSpermidine

Identifiers

PMID41078867
PMCPMC12513291

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.