ArticleFrontiers in neurology2025
Efficacy of repetitive transcranial magnetic stimulation for disorders of consciousness: a retrospective cohort study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in the treatment of patients with disorders of consciousness (DoC) in a real-world setting, and to analyze the relevant factors affecting efficacy. Method: Using a single-center retrospective cohort study design based on a hospital information system, we reviewed all patients with DoC presenting to the rehabilitation unit of our hospital between October 2019 and October 2024. Efficacy was assessed using the Glasgow Coma Scale (GCS), with the presence or absence of rTMS as an exposure factor. Results: The exposed group did not significantly improve the GCS scores of patients with DoC compared to the non-exposed group. The Subgroup analysis showed that rTMS improved the level of consciousness in patients with stroke compared to the non-exposed group ( Conclusion: rTMS did not significantly improve the GCS scores of patients with DoC. However, it may improve the level of consciousness of patients with stroke-induced or moderate DoC. Nevertheless, this conclusion requires validation through rigorous, standardized, large-sample randomized controlled trials (RCTs).
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