Evidence map›Paper›PMID 41079481›Full record

SynthesisFrontiers in neuroscience2025

Frontiers of optic nerve regeneration research: an analysis of the top 100 most influential articles in the field from 2005 to 2025.

Saijilafu, Peng Chen, Lingchen Ye, Yuxi Shen, Qi Wang, Xuanwen Chen, Chimedragchaa Chimedtseren, Junqian Zhang, Linjun Fang, Renjie Xu

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saijilafu *Hangzhou Lin'an Traditional Chinese Medicine Hospital, Affiliated Hospital, Hangzhou City University, Hangzhou, Zhejiang, China.
Peng Chen *Department of Orthopedics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Lingchen YeDepartment of Orthopedics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Yuxi ShenKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, China.
Qi WangKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, China.
Xuanwen ChenKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, China.
Chimedragchaa ChimedtserenInstitute of Traditional Medicine and Technology of Mongolia, Ulaanbaatar, Mongolia.
Junqian ZhangKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, China.
Linjun FangHangzhou Lin'an Traditional Chinese Medicine Hospital, Affiliated Hospital, Hangzhou City University, Hangzhou, Zhejiang, China.
Renjie XuDepartment of Orthopedics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: In this study, we evaluated the key features of the 100 most-cited publications on optic nerve regeneration from 2005 to 2025 employing bibliometric and visual analysis. Methods: The data for this study were obtained from a comprehensive search across multiple databases, including the Web of Science, Scopus, and Dimensions. We identified the top 100 most-cited articles published in each database from 2005 to 2025, merged and deduplicated the results, and selected the 100 most-cited papers on optic nerve regeneration. After extracting key details such as titles, authors, keywords, publication information, and institutional affiliations, a bibliometric analysis was conducted. Results: The top 100 most cited papers on optic nerve regeneration published between 2005 and 2025, accumulating 34,636 total citations with a median of 346 citations per paper. Prof. Zhigang He emerged as the most prolific author with 19 publications. The United States contributed 59 papers, while Harvard University led institutions with 30 publications. Key research themes included optic nerve regeneration, CNTF, gene therapy, and retinal ganglion cells. Conclusion: Our analysis of top-cited optic nerve regeneration research reveals sustained United States leadership in output and innovation. Early work focused on neuronal signaling pathways (PTEN/mTOR, KLF family), while current studies explore novel targets and biomaterials. Global collaboration among the United States, China, and European nations has accelerated progress. Key challenges remain in achieving functional long-distance regeneration. Future direction should prioritize the development of multi-target therapeutic methods, precise drug delivery, and the control of inflammation to improve nerve regeneration efficiency.

Indexed as

bibliometric analysisCiteSpaceoptic nerve regenerationVOS viewerweb of science core collection

Identifiers

PMID41079481
PMCPMC12507791

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.