Evidence map›Paper›PMID 41079624›Full record

ArticleiScience2025

Proximity and metabolic activity proxies in the tumor microenvironment as predictors of survival in high grade serous ovarian cancer.

Naomi Berrell, Aaron Kilgallon, Meg L Donovan, Clara Lawler, Chin Wee Tan, Kidane S Embaye, Rafael Tubelleza, James Monkman, John F Fraser, Ken O'Byrne and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Naomi BerrellQueensland Spatial Biology Centre, Wesley Research Institute, The Wesley Hospital, Brisbane, QLD 4066, Australia.
Aaron KilgallonQueensland Spatial Biology Centre, Wesley Research Institute, The Wesley Hospital, Brisbane, QLD 4066, Australia.
Meg L DonovanQueensland Spatial Biology Centre, Wesley Research Institute, The Wesley Hospital, Brisbane, QLD 4066, Australia.
Clara LawlerFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
Chin Wee TanBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia.
Kidane S EmbayeFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
Rafael TubellezaFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
James MonkmanFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
John F FraserQueensland Spatial Biology Centre, Wesley Research Institute, The Wesley Hospital, Brisbane, QLD 4066, Australia.
Ken O'ByrneQueensland University of Technology, Woolloongabba, QLD 4012, Australia.
Ruby HuangSchool of Medicine, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Arutha KulasingheQueensland Spatial Biology Centre, Wesley Research Institute, The Wesley Hospital, Brisbane, QLD 4066, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High grade serous ovarian cancer (HGSOC) is a lethal gynecological malignancy, often detected at the late stages of disease. There is a need to identify predictors of therapeutic response in the tumor microenvironment (TME). Here, we used spatial proteomics to characterize the TME of 51 patients with HGSOC and identify features that contribute to patient survival. Using a 48-plex immunofluorescent protein panel, we analyzed tumor and immune cell interactions. We identified that more CD66

Indexed as

CancerImmune responseMicroenvironmentOmics

Identifiers

PMID41079624
PMCPMC12514571

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.