Evidence map›Paper›PMID 41079694›Full record

ArticleData in brief2025

Data showing effects of resolvin D

Wenyan Li, Claes Dahlgren, Huamei Forsman

Abstract read
In one paragraph

Article in Data in brief, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wenyan LiDepartment of Respiratory Medicine, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University; Guangdong Provincial Clinical Research Centre for Child Health, Guangzhou 510623, China.
Claes DahlgrenDepartment of Rheumatology and Inflammation research, University of Gothenburg, Gothenburg 40530, Sweden.
Huamei ForsmanDepartment of Rheumatology and Inflammation research, University of Gothenburg, Gothenburg 40530, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulation of the reactive oxygen species (ROS) producing NADPH oxidase, expressed in neutrophils, is essential for a balance between the proinflammatory antimicrobial host defence and the resolving reactivity that limits tissue destructing inflammatory processes. Peripheral blood neutrophils of healthy adults were isolated from buffy coats obtained from the blood bank at Sahlgrenska University Hospital, using a standard density-gradient centrifugation protocol. The neutrophils were activated by fMet-Leu-Phe (fMLF) a peptide recognized by formyl peptide receptor 1 (FPR1). Signals generated downstream of the agonist occupied FPR1 activate the NADPH oxidase in the neutrophil plasma membrane. The release of ROS by fMLF activated neutrophils was measured in real time using a very sensitive isoluminol-amplified chemiluminescence system, expressed in light units (Mega counts per minute; Mcpm), and the peak value levels of the responses were determined. The activation signals generated by FPR1 were inhibited (reduced peak values) by the agonist occupied EP

Indexed as

Allosteric modulationEP4FPR1G protein coupled receptorsPGE2SPNs

Identifiers

PMID41079694
PMCPMC12510081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.