Evidence map›Paper›PMID 41079935›Full record

ArticleInternational journal of biological sciences2025

TPL2 Promotes Gastric Cancer Progression and Chemoresistance Through a Hypoxia-Induced Positive Feedback Loop with PPARδ.

Keng-Li Lan, De-Wei Lai, Cheng-Ning Yang, Hung-Chuan Pan, Hui-Ting Ou, Szu-I Yu, Tsung-Che Hsieh, Yi-Lun Ye, Chia-Yang Chan, Kin-Long Chou and 8 more

Abstract read
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In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Keng-Li LanInstitute of Traditional Medicine, College of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan.
De-Wei LaiDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Cheng-Ning YangDepartment of Dentistry, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hung-Chuan PanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Hui-Ting OuInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Szu-I YuInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Tsung-Che HsiehInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Yi-Lun YeInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Chia-Yang ChanInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Kin-Long ChouInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Sheng-Mao WuInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Li-Wei ShenInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Chin-Chang ShenInstitute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan.
Lujen ChenDepartment of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Shing-Hwa LiuInstitute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chien-Shan ChiuDepartment of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan.
Jack L ArbiserDepartment of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta Veterans Administration Health Center, Atlanta, Georgia, USA.
Meei-Ling SheuDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor progression locus 2 (TPL2), a member of the MAP3K serine/threonine protein kinase family, is implicated in immune responses and pro-inflammatory protein phosphorylation. Emerging evidence suggests its role in tumorigenesis; however, its contribution to gastric cancer (GC) development remains unclear. Patients' disease progression and tumor tissues obtained were used to perform gene expression and GSEA analysis. Immunohistochemical staining,

Indexed as

MAP Kinase Kinase KinasesPPAR deltaProto-Oncogene ProteinsStomach NeoplasmsAnimalsCell Line, TumorCell ProliferationDisease ProgressionDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudeMAP3K8 protein, humanMAP Kinase Kinase KinasesPPAR deltaProto-Oncogene ProteinschemoresistancehypoxiaPPARδproliferationTPL2

Identifiers

PMID41079935
PMCPMC12509916

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.