Evidence map›Paper›PMID 41081248›Full record

ArticleNeuroimage. Reports2025

Test-retest reliability of template-defined vs. manual tracing processing streams in neuromelanin-sensitive magnetic resonance imaging analysis.

Tyler A Lesh, Jason Smucny, Joshua P Rhilinger, Sarvenaz Pakzad, Guillermo Horga, Cameron S Carter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroimage. Reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tyler A LeshDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, 1 Shields Ave, Davis, CA, 95616, USA.
Jason SmucnyDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, 1 Shields Ave, Davis, CA, 95616, USA.
Joshua P RhilingerDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, 1 Shields Ave, Davis, CA, 95616, USA.
Sarvenaz PakzadDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, 1 Shields Ave, Davis, CA, 95616, USA.
Guillermo HorgaDepartment of Psychiatry, Columbia University, 116th and Broadway, New York, NY, 10027, USA.
Cameron S CarterDepartment of Psychiatry and Human Behavior, University of California, Irvine, 401 E. Peltason Drive, Irvine, CA, 92617, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromelanin (NM) magnetic resonance imaging (MRI) is a relatively new, noninvasive method used as a proxy measure of midbrain dopamine function. Previous studies in schizophrenia have found evidence of enhanced signal in patients that are associated with positive psychotic symptoms. However, there are limited data available comparing methods of computing signal in substantia nigra (SN). We sought to examine the reliability and validity of manual tracing vs template-defined methods to help guide the field in identifying optimal approaches in NM imaging. NM-MRI was performed on 22 participants (18 with early psychosis (EP) and 4 healthy controls (HCs)) scanned twice over a 1-14 week period. Mean SN NM signal was calculated using template-defined and manual tracing methods to define SN ROIs. Intraclass correlation coefficients (ICCs) based on absolute agreement were calculated between test and retest. Correlations between NM signal for each method and symptoms in EP were also examined. ICCs for the template-defined were in the excellent range (.81-.85) and manual tracing methods were in the poor to fair range (-.14 to .56). The template-defined method showed a trend positive relationship with reality distortion symptoms (r = .45,

Indexed as

DopamineMRINeuromelaninPsychosisSchizophreniaSubstantia nigra

Identifiers

PMID41081248
PMCPMC12509897

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.