ReviewReviews in endocrine & metabolic disorders2026
Hypothalamic ceramide metabolism in obesity and dysregulation of glucose homeostasis.
Review in Reviews in endocrine & metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hypothalamic wars: the last nanodelivery.Reviews in endocrine & metabolic disorders · 2026Review
- Attack of the kinases: JNK signaling in metabolism.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central nervous system is a key regulator of energy and glucose homeostasis, integrating peripheral signals such as hormones and nutrients to maintain metabolic balance. Among its regions, the hypothalamus plays a central role in monitoring energy status and orchestrating physiological responses via neuronal and glial circuits. Recent research highlights the influence of de novo ceramide synthesis on central nervous system regulation of metabolism. Indeed, ceramides have emerged as critical signalling molecules linking fatty acid sensing to hypothalamic control of feeding, energy expenditure, and glucose regulation. This review details the mechanisms of de novo ceramide synthesis and explores how dysregulation of this pathway in the hypothalamus contributes to obesity and type 2 diabetes. Serine palmitoyl-transferase and specific ceramide synthase isoforms are shown to play roles in mediating neuronal responses to metabolic stress. The findings also emphasize that hypothalamic ceramide metabolism is modulated by both nutritional and hormonal cues and suggest that targeting this pathway may offer new strategies for treating metabolic disorders.
Indexed as
Identifiers
41082169What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.