Evidence map›Paper›PMID 41082272›Full record

Observational studyMicrocirculation (New York, N.Y. : 1994)2025

Observational Study of Sublingual Microcirculation in Patients With Chronic Cardiovascular Disease.

Jacob Niculcea, James W Schurr, Fatima M Talebi, Joyce W Wald, John C Greenwood

Abstract readObservational Study
In one paragraph

Observational study in Microcirculation (New York, N.Y. : 1994), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jacob NiculceaDivision of Cardiovascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0009-0005-4133-0721
James W SchurrDivision of Cardiovascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Fatima M TalebiTouro College of Osteopathic Medicine, New York, New York, USA.
Joyce W WaldDivision of Cardiovascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
John C GreenwoodDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

1/2 ICECAP: Influence of Cooling duration on Efficacy in Cardiac Arrest PatientsUH3HL145269 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GEOCADIN, ROMERGRYKO, MEURER, WILLIAM JOSEPH · 2020 to 2024
$21.4M
The Use of Blood Cells and Optical Cerebral Complex IV Redox States in a Porcine Model of CO Poisoning with Evaluation of Mitochondrial TherapyR01HL166592 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DAVID H JANG · 2023 to 2026
$2.8M
NHLBI NIH HHS R01 HL166592NHLBI NIH HHS R01HL166592NHLBI NIH HHS UH3 HL145269NHLBI NIH HHS UH3HL145269University of Pennsylvania Abramson Emergency Medicine & Critical Care Research Fund
6 · The paper itself

Abstract

backgroundSublingual video microscopy is increasingly used to study the microcirculation in acute illness. However, the sublingual microcirculation in patients with chronic cardiovascular diseases (CVD) is understudied. Our objective was to quantify sublingual microcirculatory parameters in a large cohort of patients with CVD.

methodsOne hundred and thirteen patients with CVD were enrolled. Incident dark-field handheld video microscopy (IDF-HVM) was used to quantify microvascular flow index (MFI), microvascular heterogeneity index (MHI), proportion of perfused vessels (PPV), perfused vessel density (PVD), and total vessel density (TVD). Data were stratified by age quartiles (20-39, 40-59, 60-79, 80+), cardiovascular comorbidities (hypertension, diabetes, chronic kidney disease, coronary artery disease, heart failure), and systemic hemodynamics (mean arterial pressure and pulse pressure).

resultsIn our 113 patient cohort, overall MFI = 2.86 ± 0.20; MHI = 0.15 ± 0.20; PPV = 94.3% ± 4.9%; PVD = 23.1 ± 4.7 mm/mm

conclusionIn patients with stable cardiovascular disease, sublingual microvascular parameters are similar across age, blood pressure, and comorbidity cohorts, with the exception of decreased MHI in diabetic patients.

Indexed as

Cardiovascular DiseasesMicrocirculationMouth FloorAdultAgedAged, 80 and overChronic DiseaseFemaleHumansMaleMiddle Aged

Identifiers

PMID41082272
PMCPMC12517397

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.