Evidence map›Paper›PMID 41082322›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Novel Bioresorbable Bone Wax for Potentiated Hemostasis and Osteogenesis.

Longbao Feng, Yanbin Lu, Pengyu Fu, Shaojun Li, Pengning She, Yang Xiao, Jiaming Ye, Wanqi Li, Shaochuan Li, Wei Xue and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Novel Bioresorbable Bone Wax for Potentiated Hemostasis and Osteogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Longbao FengKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Key Laboratory of Regenerative Medicine of Ministry of Education, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Yanbin LuKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Key Laboratory of Regenerative Medicine of Ministry of Education, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Pengyu FuKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Key Laboratory of Regenerative Medicine of Ministry of Education, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Shaojun LiKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Key Laboratory of Regenerative Medicine of Ministry of Education, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Pengning SheCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510640, China.
Yang XiaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510640, China.
Jiaming YeCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510640, China.
Wanqi LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510640, China.
Shaochuan LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510640, China.
Wei XueKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Key Laboratory of Regenerative Medicine of Ministry of Education, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Rui GuoKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Key Laboratory of Regenerative Medicine of Ministry of Education, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.ORCID https://orcid.org/0000-0002-7674-073X

Funding

Key Technologies Research and Development Program of Guangzhou Municipality 2024B03J1244National High-tech Research and Development Program 2320197001409National Key Research and Development Program of China 2022YFC2403102Special Project for Research and Development in Key areas of Guangdong Province 2022B1111080007
6 · The paper itself

Abstract

Orthopedic surgery faces dual challenges of uncontrolled bleeding and poor bone regeneration at defect sites. While traditional beeswax-based hemostats remain clinically prevalent, their non-resorbability impedes healing and triggers chronic inflammation. This study introduces a "hemostasis-resorption-osteogenesis" synergistic design paradigm, developing a novel bioresorbable bone wax based on a polymer dispersion matrix that integrates a quaternized cationic starch (QS) and β-tricalcium phosphate (β-TCP) dual-phase promoting matrix (PST). PST bone wax's physicochemical properties, characterized via finger pressing models and in vitro sealing assays, demonstrate excellent plasticity and adhesiveness, enabling rapid sealing and prolonged hemostasis under physiological blood pressure. It gradually resorbs, releasing Ca

Indexed as

HemostasisHemostaticsOsteogenesisPalmitatesWaxesAnimalsBone RegenerationCalcium PhosphatesDogsHumansMesenchymal Stem CellsRabbitsbeta-tricalcium phosphatebone waxCalcium PhosphatesHemostaticsPalmitatesWaxesbone hemostasisosteogenesisquaternized cationic starchresorbable biomaterialβ‐TCP

Identifiers

PMID41082322
PMCPMC12786301

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.