Evidence map›Paper›PMID 41083510›Full record

ArticleScientific reports2025

Urine phospholipid profiling in patients with rheumatoid arthritis and nontuberculous mycobacterial pulmonary disease.

Hiroshi Furukawa, Shomi Oka, Takashi Higuchi, Akira Okamoto, Misuzu Fujimori, Toshihiro Matsui, Atsushi Ihata, Fuminori Hirano, Akitomo Okada, Kiyoshi Migita and 1 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hiroshi FurukawaDepartment of Rheumatology, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, 204-8585, Japan. furukawa-tky@umin.org.
Shomi OkaDepartment of Rheumatology, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, 204-8585, Japan.
Takashi HiguchiDepartment of Rheumatology, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, 204-8585, Japan.
Akira OkamotoDepartment of Rheumatology, NHO Himeji Medical Center, 68 Hon-Machi, Himeji, 670-8520, Japan.
Misuzu FujimoriDepartment of Rheumatology, NHO Himeji Medical Center, 68 Hon-Machi, Himeji, 670-8520, Japan.
Toshihiro MatsuiClinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392, Japan.
Atsushi IhataDepartment of Rheumatology, NHO Yokohama Medical Center, 3-60-2 Harajuku, Totsuka-Ku, Yokohama, 245-8575, Japan.
Fuminori HiranoDepartment of Internal Medicine, NHO Asahikawa Medical Center, 7-4048 Hanasakicho, Asahikawa, 070-8644, Japan.
Akitomo OkadaClinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, Omura, 856-8562, Japan.
Kiyoshi MigitaDepartment of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Shigeto TohmaDepartment of Rheumatology, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, 204-8585, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Study participants with rheumatoid arthritis (RA) have an elevated risk for nontuberculous mycobacterial pulmonary disease (NTM-PD), which limits the treatments for RA. Biomarkers for NTM-PD in study participants with RA are required. Patients with NTM-PD have been studied for small-molecule metabolites, although few have been performed for NTM-PD associated with RA. Therefore, we performed lipidomic profiling of NTM-PD in the urine specimens of study participants with RA to discover useful biomarkers. Urine specimens provided by 90 study participants with RA, with or without NTM-PD were subjected to lipidomic analysis. Univariate analysis found that the urinary concentrations of lysophosphatidic acid (LPA) 22:5 and phosphatidic acid (PA) 36:1 were altered in study participants with RA and NTM-PD (respective areas under the curves of receiver operating characteristic (AUROCs) were 0.977 and 0.811; P = 3.83 × 10

Indexed as

Arthritis, RheumatoidLung DiseasesMycobacterium Infections, NontuberculousPhospholipidsAdultAgedBiomarkersFemaleHumansLipidomicsLysophospholipidsMaleMiddle AgedBiomarkerslysophosphatidic acidLysophospholipidsPhospholipidsMetabolomicsNon-tuberculous mycobacterial pulmonary diseasePhospholipidRheumatoid arthritis

Identifiers

PMID41083510
PMCPMC12518530

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.