Evidence map›Paper›PMID 41083637›Full record

ArticleDoklady. Biochemistry and biophysics2025

Differential Methylation of the Genes PAX8 and GATA4 Alters Their Expression in the Heart during Hypertrophic Cardiomyopathy.

I S Kiselev, E A Dashtieva, M V Pisklova, O S Chumakova, A S Zotov, M R Kabilov, O A Baturina, D A Zateyshchikov, O O Favorova

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Article in Doklady. Biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

I S KiselevChazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia. kiselev.ivan.1991@gmail.com.
E A DashtievaChazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
M V PisklovaChazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
O S ChumakovaChazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
A S ZotovChazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
M R KabilovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
O A BaturinaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
D A ZateyshchikovChazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
O O FavorovaChazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is the most common hereditary heart disease with a prevalence ranging from 1 : 500 to 1 : 200 individuals. The development and clinical presentation of HCM do not always conform to the traditional view of its monogenic inheritance pattern. One key to addressing this issue may lie in identifying epigenetic mechanisms regulating gene expression, particularly DNA methylation, involved in the pathogenesis of the disease and modifying its course. Using previously obtained whole-genome data, we identified four extended genomic regions with reduced methylation levels in the myocardium of patients with HCM. These include region chr2:113993204-113994075, located within the transcribed area of the PAX8 gene, as well as three other regions (chr6:31148369-31148577, chr8:11565217-11567212, and chr8:22132791-22133357), which are associated with promoters of genes PSORS1C3, GATA4, and PIWIL2, respectively. We demonstrated altered expression of PAX8 and GATA4 genes containing one each of these four mentioned regions. Our findings will expand the currently very limited understanding of the unique features of epigenetic regulation in this condition.

Indexed as

Cardiomyopathy, HypertrophicDNA MethylationGATA4 Transcription FactorGene Expression RegulationMyocardiumPAX8 Transcription FactorAdultEpigenesis, GeneticFemaleHumansMaleMiddle AgedGATA4 protein, humanGATA4 Transcription FactorPAX8 protein, humanPAX8 Transcription Factordifferentially methylated genomic regionsDNA methylationepigenetic regulation of gene expressiongene expression analysisHypertrophic cardiomyopathy

Identifiers

PMID41083637

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.