ArticleScientific reports2025
Biocompatibility and structural insights of seaweed-derived cellulose scaffolds in a subcutaneous implantation model.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Early Biocompatibility of Brown Macroalgal Scaffolds in a Splinted Full-Thickness Rodent Wound Model: A Pilot Study.Journal of functional biomaterials · 2026Article
- From Design to Application: Advanced Cellulose Scaffolds for Engineered Tissue Regeneration.Polymers · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Sustainable biomaterials are essential for advancing tissue engineering. This study investigates the in vivo biocompatibility and regenerative potential of seaweed cellulose (SC) scaffolds derived from Ulva sp. and Cladophora sp. as connective support matrices. SC scaffolds were fabricated using an optimized decellularization process that preserved their distinct porous (Ulva) and fibrous (Cladophora) architectures. Subcutaneous implantation in Sprague-Dawley rats demonstrated minimal foreign body response and successful integration over an eight-week period. Histological analysis revealed architecture-driven healing dynamics: Ulva sp. scaffolds promoted compartmentalized healing, characterized by distributed vascularized connective tissue, while Cladophora sp. scaffolds supported stratified tissue organization with aligned collagen deposition. Both scaffolds exhibited progressive vascularization and reduced foreign body response, with no adverse inflammatory reactions observed. These findings highlight the potential of SC scaffolds for regenerative applications that require tailored tissue responses, while their renewable, marine- origin underscores their potential as sustainable biomaterials in advanced healthcare solutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.