ReviewMammalian genome : official journal of the International Mammalian Genome Society2025
MicroRNA dysregulation in male infertility: Insights into mechanisms, biomarkers, and therapeutic strategies- review.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Infertility affects ~ 15% of couples globally, with male factors contributing to ~ 50% of cases. Male infertility comes from a variety genetic, hormonal, environmental, and lifestyle factors. Yet, a large proportion of cases are idiopathic and have no identifiable cause. Recent advances highlight the critical role of microRNAs (miRNAs), small non-coding RNAs that regulate gene expression at the post-transcriptional level, in male reproductive health. miRNAs are pivotal in spermatogenesis, sperm maturation, and testicular function, influencing processes such as cell cycle regulation, apoptosis, and differentiation. Altered miRNA expression has been linked to many types of male infertility, such as oligozoospermia (low sperm count), asthenozoospermia (low motility), azoospermia(no sperm) and teratozoospermia(abnormal morphology). Notably, miRNAs like miR-34c, miR-21, and miR-449 play essential roles in germ cell proliferation, meiotic progression, and spermiogenesis, while others, such as miR-210 and miR-122, impact sperm motility and DNA integrity.Their stability in biological fluids positions miRNAs as promising non-invasive biomarkers for diagnosing male infertility. miRNA-based diagnostics significantly reduce the need for invasive testicular biopsies in men with azoospermia, enabling earlier, less invasive, and more accurate identification of underlying spermatogenic defects. Furthermore, miRNA-targeted therapies hold promise for restoring spermatogenesis in select cases, potentially improving fertility outcomes for affected patients. Moreover, therapeutic approaches targeting miRNA pathways, including miRNA mimics and inhibitors, offer innovative solutions to restore reproductive function. However, challenges such as complex miRNA networks, delivery system inefficiencies, and inter-individual variability hinder clinical translation. The various functions of miRNAs in male infertility are highlighted in this review, along with their potential for diagnosis, prognosis, and treatment.
Indexed as
Identifiers
41083795What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.