Evidence mapPaperPMID 41087039Full record

ArticleAmerican journal of physiology. Renal physiology2025

Renal tubular (pro)renin receptor deletion exacerbates kidney injury in

Deborah Stuart, Caitlin S Peterson, Dhruvan Gopinath, Divya Sundar, Will Wheatley, Nirupama Ramkumar

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Deborah StuartDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Utah Health, Salt Lake City, Utah, United States.
Caitlin S PetersonDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Utah Health, Salt Lake City, Utah, United States.
Dhruvan GopinathDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Utah Health, Salt Lake City, Utah, United States.
Divya SundarDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Utah Health, Salt Lake City, Utah, United States.
Will WheatleyDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Utah Health, Salt Lake City, Utah, United States.
Nirupama RamkumarDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Utah Health, Salt Lake City, Utah, United States.ORCID 0000-0002-5312-1100

Funding

Soluble (pro)renin receptor regulation of kidney fibrosisR01DK133271 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$452k
American Diabetes Association (ADA) Junior faculty development grantHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL155345HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK133271NHLBI NIH HHS R56 HL155345NIDDK NIH HHS R01 DK133271
6 · The paper itself

Abstract

The (pro)renin receptor (PRR) is a multifunctional protein implicated in blood pressure regulation and kidney fibrosis. Previous studies report enhanced PRR expression in nondiabetic and diabetic kidney disease. In this study, we investigated whether deletion of renal tubular PRR attenuates kidney injury in type 2 diabetes. Floxed PRR mice were bred with mice expressing Pax8 rtTA and LC1 transgenes and

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesKidney TubulesReceptors, Cell SurfaceVacuolar Proton-Translocating ATPasesAlbuminuriaAnimalsBlood GlucoseDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutProrenin ReceptorATP6AP2 protein, mouseBlood GlucoseProrenin ReceptorReceptors, Cell SurfaceVacuolar Proton-Translocating ATPasesdiabeteskidney disease(pro)renin receptor

Identifiers

PMID41087039
PMCPMC12643321

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.