Evidence map›Paper›PMID 41087294›Full record

ReviewZeitschrift fur medizinische Physik2026

In vivo corneal microscopy: from image to insight - where are we going?

Karsten Sperlich, Sebastian Bohn, Florian Worsch, Luisa H Colorado, Stephan Allgeier, Oliver Stachs

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Zeitschrift fur medizinische Physik, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karsten SperlichDepartment of Ophthalmology, Rostock University Medical Center, Rostock, Germany; Department Life, Light & Matter, University of Rostock, Rostock, Germany.
Sebastian BohnDepartment of Ophthalmology, Rostock University Medical Center, Rostock, Germany; Department Life, Light & Matter, University of Rostock, Rostock, Germany. Electronic address: sebastian.bohn@uni-rostock.de.
Florian WorschDepartment of Ophthalmology, Rostock University Medical Center, Rostock, Germany; Department of Optometry, Beuth University of Applied Sciences, Berlin, Germany.
Luisa H ColoradoCentre for Vision and Eye Research, School of Clinical Sciences, Optometry and Vision Science, Queensland University of Technology, Brisbane, QLD, Australia.
Stephan AllgeierInstitute for Automation and Applied Informatics, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Oliver StachsDepartment of Ophthalmology, Rostock University Medical Center, Rostock, Germany; Department Life, Light & Matter, University of Rostock, Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vivo confocal microscopy (IVCM) enables noninvasive imaging of the human cornea at cellular resolution, making it an indispensable diagnostic tool in clinical ophthalmology and biomedical research. The combination of the Heidelberg Retina Tomograph (HRT) and the Rostock Cornea Module (RCM) has established itself as the gold standard for corneal cellular imaging. This review summarizes the imaging principles, technological advancements, and clinical applications of IVCM. It highlights recent advancements, including automated large-area mosaicking of the subbasal nerve plexus, three-dimensional volumetric imaging, time-lapse imaging, and enhanced image analysis techniques. Additionally, corneal immune cell dynamics, critical to understanding corneal pathophysiology, are highlighted. Future challenges and developments aimed at improving diagnostic accuracy and clinical applicability are discussed.

Indexed as

CorneaAnimalsHumansImaging, Three-DimensionalMicroscopy, ConfocalCorneal imagingCorneal nervesIn vivo confocal microscopyOcular surfaceTranslational research

Identifiers

PMID41087294
PMCPMC13316519

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.