Evidence map›Paper›PMID 41087621›Full record

ArticleGeroScience2026

Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human.

Jose A Godoy-Lugo, Max A Thorwald, Elizabeth Head, Ashley L Gomm, Can Zhang, Rudolph E Tanzi, Caleb E Finch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jose A Godoy-LugoLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Max A ThorwaldLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California at Irvine, Irvine, CA, USA.
Ashley L GommGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA, USA.
Can ZhangGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA, USA.
Rudolph E TanziGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA, USA.
Caleb E FinchLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA. cefinch@usc.edu.

Funding

VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUI, HELENA CHANG · 1985 to 2019
$41.0M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5M
Amyloid and inflammation: modulation by apoE, gender, air pollution, and drugsRF1AG051521 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, CALEB E · 2015 to 2015
$3.0M
NIA NIH HHS AG006781NIA NIH HHS AG05142NIA NIH HHS AG051521NIA NIH HHS AG055367NIA NIH HHS AG066509NIA NIH HHS AG066519NIA NIH HHS AG066530NIA NIH HHS P01 AG055367NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P50 AG005142NIA NIH HHS RF1 AG051521NIA NIH HHS U01 AG006781
6 · The paper itself

Abstract

Age increases of brain amyloid plaques may be mediated by prior increase of soluble Aβ42. Here, we show that frontal cortex samples from brains of cognitively normal aging humans had progressively increased levels of soluble amyloid peptide Aβ40 throughout the lifespan. Aggregated amyloid fraction was subsequently obtained by formic acid, where Aβ42 showed increases only in humans over 90 years old when compared to those younger than 50. Similarly, aging wild-type mice without amyloid plaques had increases of both soluble Aβ40 and Aβ42, as previously shown in normal aging rats. Aging also alters secretase enzymes and processing of amyloid precursor protein (APP). Here, we isolate membrane domains known as lipid rafts, a site of APP cleavage. We found that lipid rafts isolated from mouse and human cerebral cortex showed age increases of β-secretase enzyme activity, while amyloidogenic secretase proteins levels BACE1 and PS1 decreased with age in mouse. Lipid rafts merit further study in aging and neurodegeneration.

Indexed as

AgingAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesBrainPeptide FragmentsAgedAged, 80 and overAnimalsFemaleFrontal LobeHumansMaleMembrane MicrodomainsMiceMice, Inbred C57BLMiddle AgedAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesPeptide FragmentsAgingAβ peptidesSecretase activity

Identifiers

PMID41087621
PMCPMC13355960

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.