Evidence map›Paper›PMID 41087623›Full record

ArticleOdontology2026

Uncovering the hidden costs of Molar Incisor Hypomineralization (MIH): the impact of later diagnosis on clinical outcomes and financial cost.

Izadora Ramos de Almeida, Lana Cardoso-Silva, Alexandra Mussolino de Queiroz, Rafaela Manente, Kamilla Martineli Mendes, Soraya Coelho Leal, David John Manton, Francisco Wanderley Garcia de Paula-Silva, Fabrício Kitazono de Carvalho

Abstract read
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In one paragraph

Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Izadora Ramos de AlmeidaRibeirão Preto School of Dentistry, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Prêto, SP, CEP 14040-904, Brazil.
Lana Cardoso-SilvaRibeirão Preto School of Dentistry, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Prêto, SP, CEP 14040-904, Brazil.
Alexandra Mussolino de QueirozRibeirão Preto School of Dentistry, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Prêto, SP, CEP 14040-904, Brazil.
Rafaela ManenteRibeirão Preto School of Dentistry, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Prêto, SP, CEP 14040-904, Brazil.
Kamilla Martineli MendesRibeirão Preto School of Dentistry, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Prêto, SP, CEP 14040-904, Brazil.
Soraya Coelho LealDepartment of Dentistry, School of Health Science, University of Brasilia, Brasília, Brazil.
David John MantonCentre for Dentistry and Oral Hygiene, UMCG, University of Groningen, Groningen, The Netherlands.
Francisco Wanderley Garcia de Paula-SilvaRibeirão Preto School of Dentistry, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Prêto, SP, CEP 14040-904, Brazil.
Fabrício Kitazono de CarvalhoRibeirão Preto School of Dentistry, University of São Paulo, Avenida do Café, s/n, Bairro Monte Alegre, Ribeirão Prêto, SP, CEP 14040-904, Brazil. fabricio_kc@forp.usp.br.ORCID http://orcid.org/0000-0002-4837-0583

Funding

National Council for Scientific and Technological Development - CNPq 405914/2021-0
6 · The paper itself

Abstract

Molar Incisor Hypomineralization (MIH) is a dynamic condition in which demarcated opacities can progress to post-eruptive enamel breakdown, increasing the risk of dental caries. This study aimed to evaluate the clinical and economic impact of late diagnosis of MIH. A total of 803 children aged 6-11 years were examined, of whom 172 were diagnosed with MIH and classified into 2 groups based on age at diagnosis: early diagnosis (under 8 years) and late diagnosis (8 years or older). A treatment plan was developed according to the severity and clinical presentation of MIH in each child, and the associated financial costs were calculated. Children in the late-diagnosis group presented more severe MIH, with a higher prevalence of demarcated opacities, atypical carious lesions, and atypical restorations. Although the estimated overall financial cost of treatment did not differ significantly between groups, a 2-year delay in MIH diagnosis led to more severe clinical presentations and higher expenses from the more complex interventions required. In conclusion, a 2-year delay in the diagnosis of MIH was associated with a more severe clinical presentation, necessitating more complex restorative treatments and leading to increased financial costs related to these treatments.Research Ethics Committee: CAAE 12161019.2.0000.5419, date 29.04.2019.

Indexed as

Delayed DiagnosisDental Enamel HypoplasiaMolar HypomineralizationChildFemaleHumansMaleTreatment OutcomeCost analysisEarly diagnosisHypomineralizationLate diagnosis

Identifiers

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.