Observational studyBMC anesthesiology2025
Evaluation of dynamic brain function in patients with different degrees of chronic pain by EEG microstate analysis.
Observational study in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03761576 (The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery
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5 authors.
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Abstract
introductionChronic pain is closely associated with functional remodeling of the central nervous system. The neuroplasticity in the brain can be characterized by the electroencephalography (EEG) microstate analysis of the static topological features of resting-state functional brain networks.
methodsSeventy-four patients undergoing spinal surgery for chronic pain were included. Preoperative resting-state EEG recordings were obtained, and patients were stratified into two groups according to their preoperative Numerical Rating Scale (NRS) pain scores. From the EEG data, four specific microstates (labeled A, B, C, and D) were extracted, and their temporal characteristics were analyzed. Statistical analysis was performed to compare the microstate characteristics between the two groups, and to examine the correlation between microstate characteristics and pain intensity.
resultsIn the high-pain (HP) group, microstate D exhibited significantly reduced occurrence frequency, time coverage, and duration compared with the low-pain (LP) group. In addition, differences in microstate transition patterns were observed between the two groups. A significant correlation was also observed between the temporal characteristics of microstate D and the preoperative pain intensity, as measured by the NRS.
conclusionAlterations in microstate dynamics during the preoperative resting state may reflect changes in brain functions among patients with chronic pain. EEG microstate analysis may be recommended for identifying changes in brain dynamics associated with chronic pain.
trial registrationThis study was registered on ClinicalTrials.gov prior to patient enrollment (Registration number: NCT03761576; Registration date: November 30, 2018).
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