ArticleJournal of inflammation research2025
Maresin 1 Alleviates Seizure Symptoms by Modulating the Crosstalk Between Inflammation and Ferroptosis.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Long-term exposure to polystyrene microplastics exacerbates seizure symptoms via lipid metabolic disruption and ferroptosis: insights from multi-omics analyses.Journal of nanobiotechnology · 2026Article
- Article
- From insult to hyperexcitability: pharmacological targeting of MyD88 and JAK/STAT3 pathways in epilepsy.Inflammopharmacology · 2026Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Epilepsy is among the most common neurological disorders in children. The persistent challenges of drug-resistant epilepsy and the adverse effects associated with antiepileptic drugs highlight the need for innovative therapeutic approaches for pediatric epilepsy. Both ferroptosis and neuroinflammation have been identified as key mechanisms in the development of epilepsy. Recent studies suggest that Maresin1 may hold therapeutic promise for neurological diseases. However, the neuroprotective effects of Maresin1, particularly through the ferroptosis pathway in the context of seizures, remain insufficiently explored. Objective: This study aimed to investigate the protective effects of MaR1 against seizures, with a focus on its regulatory role in neuroinflammation and neuronal ferroptosis. Methods: Seizure severity was evaluated using the modified Racine scale. Cognitive abilities were assessed via the Morris Water Maze and Novel Object Recognition tests. Magnetic Resonance Imaging was used to determine hippocampal iron accumulation. Nissl staining quantified neuronal density, while Transmission Electron Microscopy examined mitochondrial ultrastructure. Western blotting was performed to analyze protein expression changes across experimental groups. Results: Pretreatment with MaR1 or a ferroptosis inhibitor significantly reduced seizure severity and improved cognitive performance in epileptic mice. Conclusion: These findings demonstrate that MaR1 can attenuate both seizure severity and cognitive impairment in epilepsy models, potentially through modulation of neuroinflammation and the ferroptosis pathway.
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Registered trials
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