ArticleFrontiers in pharmacology2025
Pre-ICU statin therapy reduces 28-day mortality in sepsis-associated brain dysfunction: a propensity-matched analysis of potential neuroprotective mechanisms.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Endothelial barrier and sepsis: mechanisms and potential therapeutic strategies.Military Medical Research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sepsis-associated brain dysfunction (SABD) is a severe complication of sepsis characterized by acute cognitive impairment and altered mental status, contributing to increased morbidity and mortality in intensive care units (ICUs). The pathophysiology involves neuroinflammation, oxidative stress, and blood-brain barrier disruption. Despite evidence suggesting potential anti-inflammatory and antioxidative properties of statins, their neuroprotective effects in SABD patients remain poorly characterized. Methods: This retrospective cohort study utilized the MIMIC-IV database (version 3.1), including adult ICU patients meeting Sepsis-3.0 criteria and diagnosed with SABD, defined as Glasgow Coma Scale (GCS) score <15 or presence of delirium. Patients with preexisting neurological disorders, chronic alcohol/substance abuse, or severe metabolic imbalances were excluded. Pre-ICU statin use was identified through prescription records. Propensity score matching (PSM) at a 1:1 ratio was performed to balance baseline characteristics between pre-ICU statin users (n = 374) and non-users (n = 374). The primary outcome was 28-day all-cause mortality, with secondary outcomes including ICU mortality, in-hospital mortality, and length of stay. Kaplan-Meier survival analysis and Cox proportional hazards regression models were utilized to assess associations between pre-ICU statin use and clinical outcomes. Results: Among 1,463 eligible patients, 412 (28.2%) received pre-ICU statin therapy. After PSM, baseline characteristics were well-balanced between groups. Kaplan-Meier analysis demonstrated significantly higher 28-day survival rates among statin users (91% vs. 85%; Conclusion: Pre-ICU statin therapy was associated with improved 28-day survival in SABD patients, potentially attributable to anti-inflammatory and antioxidant mechanisms. Despite limitations inherent in its retrospective design, this study suggests that statins may represent a promising therapeutic option for SABD patients. Prospective randomized controlled trials are warranted to validate these findings and optimize treatment protocols for this vulnerable population.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.