Evidence map›Paper›PMID 41090347›Full record

ArticleThe Journal of clinical investigation2025

Staphylococcus aureus accessory gene regulator quorum-sensing system inhibits keratinocyte lipid enzymes and delays wound repair.

Michelle D Bagood, Jelena Marjanovic, Nina Jiang, Hung Chan, Tatsuya Dokoshi, Kellen J Cavagnero, Fengwu Li, Andrea Roso-Mares, Samia Almoughrabie, Edward Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michelle D BagoodDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.
Jelena MarjanovicWound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Nina JiangDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.
Hung ChanDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.
Tatsuya DokoshiDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.
Kellen J CavagneroDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.
Fengwu LiDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.
Andrea Roso-MaresDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.
Samia AlmoughrabieDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.
Edward LiuDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.
Irena PastarWound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Marjana Tomic-CanicWound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Richard L GalloDepartment of Dermatology, University of California San Diego, La Jolla, California, USA.

Funding

Microbiology and Metagenomics CoreP50AR080594 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$9.2M
RESEARCH IN INFECTIOUS DISEASEST32AI007036 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 1985 to 2025
$9.2M
Cathelicidin in Skin ImmunityR37AI052453 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo, Victor Nizet · 2019 to 2026
$4.6M
Quorum sensing, diversity and skin inflammationR01AI153185 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GALLO, RICHARD L, HORSWILL, ALEXANDER R · 2020 to 2024
$3.2M
Prevention of intracellular infection in diabetic wounds by commensal Staphylococcus epidermidisR01DK136241 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Irena Pastar, NATASA STRBO · 2023 to 2026
$2.8M
Inflammatory cross-talk between skin and gutR01DK128787 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, SALZMAN, NITA H · 2021 to 2024
$2.6M
NIAID NIH HHS R01 AI153185NIAID NIH HHS R37 AI052453NIAID NIH HHS T32 AI007036NIAMS NIH HHS P50 AR080594NIDDK NIH HHS R01 DK128787NIDDK NIH HHS R01 DK136241
6 · The paper itself

Abstract

Mechanisms responsible for delayed wound repair are poorly understood despite the common impact of this disorder on health. To study how Staphylococcus aureus disrupts healing, mouse and human wound repair models were evaluated after exposure to S. aureus or commensal Staphylococcus. Quorum sensing by S. aureus, but not S. hominis, delayed repair and inhibited the expression of genes responsible for lipid metabolism in keratinocytes. S. aureus with inactive accessory gene regulator (agr) did not delay healing, and the inhibition of lipid metabolism was recapitulated in vitro by synthetic phenol soluble modulin α1 (psmα1) and psmα4, genes that are under agr control. However, S. aureus strains with single deletion of psmA, psmB, alpha-hemolysin (hla), or hld gene continued to delay repair, suggesting that S. aureus used multiple agr-dependent virulence factors to disrupt healing. These observations provide insight into mechanisms for delayed wound healing, identify quorum sensing as a critical event, and highlight the role of lipid biosynthesis in wound reepithelialization.

Indexed as

Bacterial ProteinsKeratinocytesLipid MetabolismQuorum SensingStaphylococcus aureusWound HealingAnimalsHumansMiceStaphylococcal InfectionsTrans-ActivatorsAgr protein, Staphylococcus aureusBacterial ProteinsTrans-ActivatorsBacterial infectionsDermatologyInfectious diseaseInnate immunitySkin

Identifiers

PMID41090347
PMCPMC12520687

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.