ArticleJournal of clinical research in pediatric endocrinology2026
Measurement of 11-Oxo-androgens, A Novel Biomarker, in Females with Clinical Signs of Premature Adrenarche
Article in Journal of clinical research in pediatric endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Endocrine findings in premature adrenarche have been characterized by elevated dehydroepiandrosterone (DHEA) DHEA-sulfate (DHEA-S) levels in the past. Methods: We reviewed female patients, aged 4 to 8 years, with premature adrenarche who were seen at a single center between 2019 and 2023. Data were collected on the traditional androgens (DHEA and DHEA-S) and novel 11-oxo-androgens, which were measured using liquid chromatography/tandem mass spectrometry assays in commercial laboratories (Lab Corp). Results: The study included 44 girls. The majority, 89% of patients from the youngest group (4-5 years olds), presented with apocrine odor as the only symptom of premature adrenarche. We have demonstrated that DHEA and DHEA-S levels were within the normal range in many girls with premature adrenarche, whereas 11-oxo-androgens, particularly 11-hydroxyandrostenedione and 11-beta-hydroxytestosterone, were elevated. Out of those with normal DHEA-S, 75% had elevated 11-hydroxyandrostenedione, and 77.8% of those patients with normal DHEA had the same elevated oxo-androgen. Moreover, advanced bone age greater than 1 year compared to chronological age was positively associated with 11-ketotestosterone [Spearman rho=0.32, 95% confidence interval (CI): 0.01-0.57, p=0.0429] and 11β-hydroxy testosterone (Spearman rho=0.32, 95% CI: 0.01-0.58, p=0.0395). Conclusion: We propose that 11-oxo-androgens are a more sensitive steroid to be measured when premature adrenarche is suspected.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.