Evidence map›Paper›PMID 41090407›Full record

ArticleDiabetes, obesity & metabolism2026

Low serum 1,5-anhydroglucitol is associated with increased risk of all-cause and cardiovascular mortality in type 2 diabetes: A real-world cohort study.

Jiaying Ni, Lei Chen, Hang Su, Jinghao Cai, Chunfang Wang, Wei Lu, Yufei Wang, Jingyi Lu, Tian Xia, Jian Zhou

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PubMed Full text at PMC Publisher
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Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jiaying NiDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Lei ChenVital Statistical Department, Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Hang SuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Jinghao CaiDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Chunfang WangVital Statistical Department, Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Wei LuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Yufei WangDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Jingyi LuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Tian XiaVital Statistical Department, Institute of Health Information, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Jian ZhouDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.ORCID 0000-0002-1534-2279

Funding

Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0532000Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0532001Shanghai Action Plan for Science, Technology and Innovation 23JS1401000Shanghai Leading Talent Program of Eastern Talent Plan LJ2024121Shanghai Oriental Talent Program (Outstanding Project)Three-year Action Program of Shanghai Municipality for Strengthening the Construction of the Public Health System GWVI-11.1-49Three-year Action Program of Shanghai Municipality for Strengthening the Construction of the Public Health System GWVI-11.2-YQ07
6 · The paper itself

Abstract

aimsSerum 1,5-anhydroglucitol (1,5-AG) indicates glycemic control over 1-2 weeks and is particularly useful for monitoring postprandial hyperglycemia. However, its predictive value for long-term outcomes in type 2 diabetes has not been fully established. Therefore, our study intends to examine the correlation between 1,5-AG and risk of all-cause and cardiovascular mortality.

methodsIn this real-world cohort study, 3721 patients with type 2 diabetes were classified by 1,5-AG levels (<6.0 and ≥6.0 μg/mL). Cox proportional hazards regression models served to analyse the link between 1,5-AG levels and risk of all-cause and cardiovascular mortality, while restricted cubic splines were employed to investigate linearity of this association.

resultsAcross a median 7.4-year follow-up duration, 528 death events were recorded, with 183 due to cardiovascular mortality. Restricted cubic spline analysis showed significant linear inverse relationships between 1,5-AG levels and risk of all-cause and cardiovascular mortality. In a fully adjusted Cox regression model including fasting plasma glucose, patients with lower 1,5-AG levels (<6.0 μg/mL) had a 43% increased risk of all-cause mortality (95% confidence interval [CI] 1.16-1.76), in contrast to individuals with higher 1,5-AG levels (≥6.0 μg/mL). For cardiovascular mortality, while categorical 1,5-AG showed an attenuated and null association (Hazard ratio 1.36, 95% CI 0.96-1.91), continuous 1,5-AG maintained a significant association.

conclusionsLower serum 1,5-AG levels were significantly linked to an elevated risk of all-cause and cardiovascular mortality in type 2 diabetes.

Indexed as

Cardiovascular DiseasesDeoxyglucoseDiabetes Mellitus, Type 2AgedBiomarkersBlood GlucoseCause of DeathCohort StudiesFemaleHumansMaleMiddle AgedProportional Hazards ModelsRisk Factors1,5-anhydroglucitolBiomarkersBlood GlucoseDeoxyglucose1,5‐anhydroglucitollong‐term consequencesmortalitytype 2 diabetes

Identifiers

PMID41090407
PMCPMC12673452

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.