Evidence map›Paper›PMID 41090728›Full record

ArticleCells2025

Optimizing the Infusion Route of Human Bone Marrow Mesenchymal Stromal Cells to Mitigate Liver Ischemia-Reperfusion Injury in a Porcine Model.

Stefan H Luijmes, Job P van Kooten, Henk P Roest, Jubi de Haan, Michail Doukas, Cornelia J Verhoeven, Kairong Wang, Jorke Willemse, Luc J W van der Laan, Monique M A Verstegen and 1 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefan H LuijmesErasmus MC Transplant Institute, Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-0348-5165
Job P van KootenErasmus MC Transplant Institute, Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Henk P RoestErasmus MC Transplant Institute, Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-4422-3807
Jubi de HaanDepartment of Intensive Care Medicine, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-7752-6532
Michail DoukasDepartment of Pathology, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-8611-840X
Cornelia J VerhoevenErasmus MC Transplant Institute, Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Kairong WangErasmus MC Transplant Institute, Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Jorke WillemseErasmus MC Transplant Institute, Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-2167-1279
Luc J W van der LaanErasmus MC Transplant Institute, Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-0651-5334
Monique M A VerstegenErasmus MC Transplant Institute, Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-9908-6673
Jeroen de JongeErasmus MC Transplant Institute, Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-1131-027X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stromal cells (MSC) have been shown to mitigate IRI through their anti-inflammatory and immune-modulating capacities. This study aims to demonstrate the feasibility, safety, and effectiveness of hepatic administration of bone marrow-derived (BM)-MSCs in a large pig model relevant to human anatomy. After complete vascular exclusion for 45 min, 3 × 10

Indexed as

Bone Marrow CellsLiverMesenchymal Stem CellsMesenchymal Stem Cell TransplantationReperfusion InjuryAnimalsDisease Models, AnimalHumansSwineischemia–reperfusion injurymesenchymal stromal cellsregenerative medicine

Identifiers

PMID41090728
PMCPMC12524216

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.