Evidence map›Paper›PMID 41091875›Full record

ArticleScience advances2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing.

Han Chen, Constantin Cretu, Abigail Trebilcock, Natalia Evdokimova, Norbert Babai, Laura Feldmann, Florian Leidner, Fritz Benseler, Sophia Mutschall, Klara Esch and 9 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Han ChenInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0009-0003-1357-5161
Constantin CretuInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-6466-176X
Abigail TrebilcockInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0009-0003-1639-9298
Natalia EvdokimovaInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0009-0009-5116-8931
Norbert BabaiInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.
Laura FeldmannInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.
Florian LeidnerDepartment of Theoretical and Computational Biophysics, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.
Fritz BenselerDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0009-0006-3846-9447
Sophia MutschallInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0009-0005-6776-4130
Klara EschInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-0729-4713
Csaba Zoltan Kibedi SzaboResearch Group Mechanisms and Regulation of pre-mRNA Splicing, The Institute of Cancer Research, London, UK.
Vladimir PenaResearch Group Mechanisms and Regulation of pre-mRNA Splicing, The Institute of Cancer Research, London, UK.ORCID 0000-0002-7013-5504
Constantin PapeCluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen, Göttingen, Germany.ORCID 0000-0001-6562-7187
Helmut GrubmüllerCluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen, Göttingen, Germany.ORCID 0000-0002-3270-3144
Nicola StrenzkeInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0003-1673-1046
Nils BroseCluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen, Göttingen, Germany.ORCID 0000-0003-0938-8534
Carolin WichmannInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0001-8868-8716
Julia PreobraschenskiInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-1825-0433
Tobias MoserInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0001-7145-0533

Funding

NCATS NIH HHS L30 TR001027Wellcome Trust 220300
6 · The paper itself

Abstract

Hearing relies upon speedy synaptic transmission of sound information from inner hair cells (IHCs) to spiral ganglion neurons. To accomplish this, IHCs use a sophisticated presynaptic machinery including the multi-C

Indexed as

Hair Cells, AuditoryHair Cells, Auditory, InnerHearingMembrane ProteinsAnimalsBinding SitesCalciumCryoelectron MicroscopyExocytosisHumansMiceMolecular Dynamics SimulationProtein BindingProtein DomainsSynapsesSynaptic TransmissionCalciumMembrane Proteinsotoferlin protein, mouse

Identifiers

PMID41091875
PMCPMC12526402

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.