Evidence mapPaperPMID 41091921Full record

ArticleJournal of Alzheimer's disease : JAD2025

Sociodemographic correlates of cognition and Alzheimer's disease and vascular biomarkers among middle to older age participants in the Healthy Brain Initiative.

Lilah M Besser, Mirza Baig, Adolfo M Henriquez, Magdalena Tolea, Deirdre M O'Shea, Stephanie Chrisphonte, Mahesh Joshi, Michael J Kleiman, James E Galvin

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lilah M BesserComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL, USA.ORCID 0000-0001-9945-0877
Mirza BaigComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL, USA.
Adolfo M HenriquezComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL, USA.ORCID 0000-0002-0584-5198
Magdalena ToleaComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL, USA.ORCID 0000-0001-5373-1331
Deirdre M O'SheaComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL, USA.ORCID 0000-0003-3313-7655
Stephanie ChrisphonteComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL, USA.
Mahesh JoshiComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL, USA.
Michael J KleimanComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL, USA.
James E GalvinComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL, USA.

Funding

Multicultural Community Dementia ScreeningR01AG071514 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2023 to 2025
$5.2M
Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural PopulationR01NS101483 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI James E Galvin · 2023 to 2023
$1.1M
Longitudinal associations between neighborhood greenspace and brain aging in cognitively normal older adultsK01AG063895 · NIA · FLORIDA ATLANTIC UNIVERSITY · PI Lilah Besser · 2022 to 2022
$126k
NIA NIH HHS K01 AG063895NIA NIH HHS R01 AG071514NINDS NIH HHS R01 NS101483
6 · The paper itself

Abstract

BackgroundKey sociodemographics (e.g., nativity) plausibly related to Alzheimer's disease and related dementia (ADRD) risk have been investigated less frequently in relation to cognitive function, brain imaging, and blood-based biomarkers.ObjectiveTo examine associations between multiple sociodemographics and ADRD/vascular outcomes among middle- to older-age adults.MethodsWe used cross-sectional data on 341 Healthy Brain Initiative participants. Outcomes included cognitive domain scores (e.g., episodic memory, language), magnetic resonance imaging (MRI) (e.g., hippocampal and white matter hyperintensity volume), and blood-based biomarkers (e.g., Aβ

Indexed as

Alzheimer DiseaseBrainCognitionAgedAged, 80 and overBiomarkersCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMemory, EpisodicMiddle AgedNeuropsychological TestsSociodemographic FactorsBiomarkersAlzheimer's diseasebiomarkerscognitionmagnetic resonance imagingsocial determinants of healthsociodemographic factors

Identifiers

PMID41091921
PMCPMC12962256

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.