Evidence map›Paper›PMID 41093288›Full record

SynthesisTropical medicine & international health : TM & IH2026

Cannabis-Derived Compounds Against Plasmodium sp.: A Systematic Review of Preclinical Studies.

Tácio de Mendonça Lima, Luann Wendel Pereira de Sena, Ana Carolina Corrêa de Sousa, Gabriel Rodrigues Martins de Freitas, Inajara Rotta, Marília Berlofa Visacri

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Tropical medicine & international health : TM & IH, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tácio de Mendonça LimaDepartment of Pharmacy and Pharmaceutical Administration, Faculty of Pharmacy, Fluminense Federal University, Niteroi, Brazil.
Luann Wendel Pereira de SenaFaculty of Collective Health, Federal University of the South and Southeast of Para, Marabá, Brazil.
Ana Carolina Corrêa de SousaFaculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Gabriel Rodrigues Martins de FreitasDepartment of Pharmaceutical Sciences, Federal University of Paraiba, Joao Pessoa, Brazil.
Inajara RottaDepartment of Pharmacy, Federal University of Parana, Curitiba, Brazil.
Marília Berlofa VisacriDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to evaluate preclinical studies on the effects and toxicity of cannabis-derived compounds against Plasmodium sp.

methodsA literature search was conducted in Web of Science, PubMed, Scopus and LILACS databases until December 2024. Studies that assessed the activity or toxicity of cannabis against Plasmodium sp. in in vitro or in vivo studies were included. Two reviewers independently performed the study selection, data extraction and methodological assessment.

resultsEight studies published between 2001 and 2022 were included, with the majority conducted in North America (n = 5). Most in vitro studies focused on assessing antimalarial activity through half-maximal inhibitory concentration (IC

conclusionsFuture studies should provide more comprehensive details on study design and further validate these findings, especially concerning toxicity.

Indexed as

AntimalarialsCannabisMalariaPlant ExtractsPlasmodiumAnimalsDrug Evaluation, PreclinicalHumansAntimalarialsPlant Extractscannabismalariaplasmodiumpreclinical drug evaluation

Identifiers

PMID41093288
PMCPMC12775889

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.