ReviewStem cell research & therapy2025
The stem cell within the vessel wall: multipotent pericytes modulating β-cell function and diabetic complications.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Proteolytic remodelling of the extracellular matrix by pericytes.The FEBS journal · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Pancreatic islet pericytes are emerging as critical regulators of β-cell development, maturation, and function beyond their traditional role in vascular support. While the roles of signaling pathways and transcription factors in β-cell development have been extensively studied, the contribution of non-endocrine components, particularly pericytes, has gained recognition as a critical regulator of β-cell biology. Originally characterized as critical component of the vasculatures, pericytes were later recognized for their role in tissue development beyond angiogenesis. This review focuses on the multifaceted contributions of pericytes to islet biology, highlighting their regulatory effects on β-cell proliferation, differentiation, and functional maturation through paracrine signaling and extracellular matrix interactions. We outlined key signaling pathways modulated by pericytes to support β-cell maturation and function. Furthermore, the complex interactions between pericytes and non-endocrine intraislet cell populations are thoroughly analyzed to elucidate the integrated microenvironmental network essential for islet development and functional homeostasis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.