Evidence map›Paper›PMID 41096534›Full record

ArticleInternational journal of molecular sciences2025

OxyVita

Waldemar Grzegorzewski, Łukasz Smyk, Łukasz Puchała, Leszek Adadynski, Marta Szadurska-Noga, Joanna Wojtkiewicz, Maria Derkaczew, Jacek Wollocko, Brian Wollocko, Hanna Wollocko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Waldemar GrzegorzewskiFaculty of Biology, Nature Protection and Sustainable Development, University of Rzeszow, str. Zelwerowicz 4, 35-601 Rzeszow, Poland.ORCID 0000-0002-3522-1327
Łukasz SmykDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, Al. Warszawska 30, 10-082 Olsztyn, Poland.
Łukasz PuchałaDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, Al. Warszawska 30, 10-082 Olsztyn, Poland.ORCID 0000-0003-0009-947X
Leszek AdadynskiDepartment of Transplantology and General Surgery, Provincial Specialist Hospital in Olsztyn, str. Zolnierska 18, 10-561 Olsztyn, Poland.
Marta Szadurska-NogaDepartment of Pathomorphology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Al. Warszawska 30, 10-082 Olsztyn, Poland.
Joanna WojtkiewiczDepartment of Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury, Al. Warszawska 30, 10-082 Olsztyn, Poland.ORCID 0000-0003-0856-3644
Maria DerkaczewDepartment of Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury, Al. Warszawska 30, 10-082 Olsztyn, Poland.
Jacek WollockoOXYVITA Inc., Middletown, NY 10940, USA.
Brian WollockoDepartment of Ophthalmology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.ORCID 0000-0002-1422-9987
Hanna WollockoOXYVITA Inc., Middletown, NY 10940, USA.ORCID 0000-0002-7351-2328

Funding

the Minister of Science under "the Regional Initiative of Excellence Program RID/SP/0025/2024/01
6 · The paper itself

Abstract

Organ transplantation has significantly progressed since the 1950s, with notable advancements in surgical procedures and immunosuppression. However, current organ preservation techniques, mainly static cold storage, have not evolved at the same pace and remain insufficient to prevent ischemic and oxidative damage. This damage, primarily caused by the cessation of aerobic metabolism, limits organ viability and transplant outcomes. In this study, we investigated whether supplementing a storage solution with a hemoglobin-based oxygen carrier (HBOC) could improve the condition of ex vivo rabbit kidneys by maintaining oxygenation and supporting aerobic metabolism. In a paired, randomized design, contralateral rabbit kidneys were preserved either in a Krebs-Ringer-based solution enriched with the polymerized hemoglobin OxyVita

Indexed as

Blood SubstitutesHemoglobinsKidneyOrgan PreservationOrgan Preservation SolutionsOxygenAnimalsKidney TransplantationMaleNecrosisRabbitsBlood SubstitutesHemoglobinsOrgan Preservation SolutionsOxygenaerobic metabolismex vivo kidney preservationhemoglobin-based oxygen carrier (HBOC)high-molecular-weight polymerkidney transplantationKrebs-Ringer’s solutionoxidative stressoxygen deliveryOxyVita®Ctubular necrosis

Identifiers

PMID41096534
PMCPMC12524553

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.