Sympathetic Biomarker Dynamics Post-Myocardial Infarction: TH, PGP9.5, and SYN Expression Discordance in Murine Hearts.

Tianshui Yu, Baoqing Pei, Dong Zhao

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Surviving Without Nerves: Intracardiac Denervation as an Underrecognized Feature of Cardiac Allograft Vasculopathy and Chronic Graft Dysfunction: A Morphological Case Report 11 Years After Transplantation.Diagnostics (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tianshui YuKey Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing 100088, China.ORCID 0009-0001-5216-4600

Baoqing PeiBeijing Key Laboratory for Design and Evaluation Technology of Advanced Implantable & Interventional Medical Devices, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.

Dong ZhaoKey Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing 100088, China.

Funding

the Defense Industrial Technology Development Program JCKY2024601C018

6 · The paper itself

Abstract

Myocardial infarction (MI) and its sequelae continue to be the leading cause of mortality globally. Following MI, a series of structural pathophysiological changes occur in the myocardium, including sympathetic remodeling. Tyrosine hydroxylase (TH), protein gene product 9.5 (PGP9.5), and synaptophysin (SYN) are recognized as key markers of sympathetic nerves. However, the expression patterns of these biomarkers during sympathetic remodeling, particularly their temporal profiles, remain insufficiently characterized. A cohort of 60 healthy adult male C57BL/6 mice was randomly divided into a control group (

Indexed as

Myocardial InfarctionMyocardiumSympathetic Nervous SystemSynaptophysinTyrosine 3-MonooxygenaseUbiquitin ThiolesteraseAnimalsBiomarkersDisease Models, AnimalMaleMiceMice, Inbred C57BLBiomarkersSynaptophysinSyp protein, mouseTyrosine 3-MonooxygenaseUbiquitin ThiolesteraseUchl1 protein, mousemyocardial infarction (MI)protein gene product 9.5 (PGP9.5)sympathetic remodelingsynaptophysin (SYN)tyrosine hydroxylase (TH)

Identifiers

PMID41096728

DOI10.3390/ijms26199456

PMCPMC12525267

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.