Evidence map›Paper›PMID 41096986›Full record

ArticleInternational journal of molecular sciences2025

Bisphenol AF Induces Hepatic Steatosis via Succinate-SUCNR1-Mediated Macrophage-Hepatocyte Interactions: An Adverse Outcome Pathway Study in Male C57BL/6 Mice.

Ning Wang, Jing Leng, Huimin Zhang, Jing Xu, Xiaoqi Yu, Kelei Qian, Zhiqing Zheng, Mengchao Ying, Gonghua Tao, Ping Xiao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ning WangShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.ORCID 0009-0005-5330-2218
Jing LengShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.
Huimin ZhangShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.
Jing XuShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.
Xiaoqi YuShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.
Kelei QianShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.
Zhiqing ZhengShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.
Mengchao YingShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.
Gonghua TaoShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.
Ping XiaoShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.
Xinyu HongShanghai Municipal Center for Disease Control and Prevention, Institute of Chemical Safety Evaluation/Key Laboratory of Environmental and Health Impact Assessment of New Pollutants, 1399 at Shenhong Road, Shanghai 201107, China.

Funding

Shanghai Natural Science Foundation 23ZR1459600Shanghai Public Health Three-Year Action Plan GWVI-11.1-41 & 42; GWVI-4
6 · The paper itself

Abstract

Bisphenol AF (BPAF) exposure is increasingly linked to metabolic disorders, yet the molecular initiating events (MIE) and key events (KE) leading to hepatic steatosis remain unclear. We constructed an adverse outcome pathway (AOP) to mechanistically connect BPAF-triggered macrophage-hepatocyte crosstalk to liver fat accumulation. Male C57BL/6 mice received daily oral gavage of 0, 0.5, 4, or 32 mg kg

Indexed as

Benzhydryl CompoundsFatty LiverHepatocytesMacrophagesPhenolsScavenger Receptors, Class ASuccinic AcidAnimalsBisphenol A CompoundsFluorocarbonsLipid MetabolismLiverMaleMiceMice, Inbred C57BLRAW 264.7 CellsBenzhydryl CompoundsBisphenol A Compoundsbisphenol AFFluorocarbonsPhenolsScavenger Receptors, Class ASuccinic AcidTriglyceridesadverse outcome pathwayBisphenol AFhepatic steatosismacrophage–hepatocyte interactionsuccinateSUCNR1

Identifiers

PMID41096986
PMCPMC12524751

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.