Evidence map›Paper›PMID 41097044›Full record

ArticleInternational journal of molecular sciences2025

4-Phenylbutyric Acid Improves Gait Ability of UBAP1-Related Spastic Paraplegia Mouse Model: Therapeutic Potential for SPG80.

Keisuke Shimozono, Yeon-Jeong Kim, Takanori Hata, Haitian Nan, Kozo Saito, Yasunori Mori, Yuji Ueno, Fujio Isono, Masaru Iwasaki, Schuichi Koizumi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [Protective effect of the endoplasmic reticulum stress inhibitor 4-phenylbutyric acid against myocardial injury in septic mice].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  2. Review
  3. Neurodegenerative Disease: From Molecular Basis to Therapy, 3rd Edition.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Keisuke ShimozonoDepartment of Neurology, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0009-0009-6443-360X
Yeon-Jeong KimDepartment of Biochemistry, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0003-1482-7319
Takanori HataDepartment of Neurology, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.
Haitian NanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.ORCID 0000-0002-1185-5464
Kozo SaitoDepartment of Neuropharmacology, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.
Yasunori MoriDepartment of Biochemistry, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.
Yuji UenoDepartment of Neurology, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0002-8617-3695
Fujio IsonoCentre for Advancing Clinical Research (CACR), Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.
Masaru IwasakiOrganization for the Promotion of Research and Social Collaboration, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0003-3766-8744
Schuichi KoizumiDepartment of Neuropharmacology, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0001-6184-3106
Toshihisa OhtsukaDepartment of Biochemistry, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0002-1566-1325
Yoshihisa TakiyamaDepartment of Neurology, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0002-5400-7107

Funding

the Education, Culture, Sports, Science, and Technology, Japan JP21K07456the Education, Culture, Sports, Science, and Technology, Japan JP24K18681the Ministry of Health, Labor and Welfare, Japan Grants-in-Aid the Research Committee for Ataxic disease
6 · The paper itself

Abstract

Spastic paraplegia 80 (SPG80), caused by mutations in

Indexed as

GaitPhenylbutyratesSpastic Paraplegia, HereditaryAnimalsDisease Models, AnimalGene Knock-In TechniquesMaleMiceMutation4-phenylbutyric acidPhenylbutyrates4-phenylbutyric acid (4-PBA)ER stresshereditary spastic paraplegia (HSP)microglia activationSPG80UBAP1

Identifiers

PMID41097044
PMCPMC12524414

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.