ReviewBioactive materials2026
Biocompatibility and immunomodulation of MXenes for targeted delivery of bioactive agents and drugs.
Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunological landscape of nanotechnology-based depression research: a bibliometric analysis of neuroinflammation and immune modulation.Frontiers in immunology · 2026Pooled it
- MXene-integrated quantum dots: an innovative tool for next-generation healthcare applications.Nanoscale advances · 2026Review
- MXenes at the Immune Interface: A Perspective on Influence of Physicochemical Design in Immunomodulation.ACS omega · 2026Review
- Review
- MXene Bioinks for 3D Bioprinting: Design and Translation.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Silica based nanocarriers for combination immunotherapy targeting the tumor immune microenvironment.Drug delivery and translational research · 2026Review
- Tantalum-Based Nanomaterials: From Properties to Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Multifunctional Nano-Contrast Agent Carriers: From Traditional Platforms to Next-Generation Theranostic Applications in Molecular Imaging.Biomedicines · 2026Review
- MXene-Based Piezoelectric and Triboelectric Energy Harvesters for Personalized Monitoring and Therapeutics.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Superhydrophobic and Water-Repellent Coatings with Dual-Scale Roughness Based on Waterborne MXene Nanocomposites.ACS applied nano materials · 2026Article
- Bioengineered extracellular vesicles escape lysosomal degradation and deliver Tet-PKM2 for macrophage immunometabolic reprogramming and periodontitis treatment.Bioactive materials · 2026Article
- Predictive Screening of TaACS nano · 2026Article
- Programmable lipid nanoparticles for RNA therapeutics: Design principles and clinical translation.Materials today. Bio · 2026Review
- Self-assembling nanocomposites for smart drug delivery: towards personalized and stimuli-responsive therapeutics.RSC advances · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MXenes, a burgeoning class of two-dimensional transition metal carbides and nitrides, have emerged as promising candidates for biomedical applications owing to their exceptional physicochemical properties and versatile surface chemistry. This review comprehensively examines the biocompatibility and immunomodulatory behavior of MXenes, with a particular emphasis on their potential in drug delivery systems. We elucidate the critical aspects of MXene-protein interactions, including protein corona formation, cellular uptake pathways, and the influence of surface functionalization on biological interfaces. Special attention is given to the immunological profile of MXenes, exploring their immunogenic potential and immunomodulatory capabilities within therapeutic contexts. Furthermore, we assess the viability of MXenes as nanocarriers for drugs and bioactive compounds, analyzing a wide array of functionalization strategies and stimuli-responsive release mechanisms aimed at enhancing therapeutic efficacy. Despite their immense potential, challenges such as long-term stability, cytotoxicity, and clinical translatability persist. We conclude by outlining these limitations and proposing strategic avenues for future research. This review serves as a vital resource for researchers at the intersection of materials science and biomedicine, particularly those advancing next-generation, two-dimensional nanomaterial-based drug delivery platforms.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.