Activation of ZBP1/RIPK3/MLKL-Dependent Necroptosis by Pseudorabies Virus Restricts Viral Infection in BV2 Microglia Cells.

Yiyu Liu, Haolin Li, Yu Dai, Jingyi Niu, Linhan Jiang, Jia Tang, Rendong Fang, Chao Ye

Abstract read

In one paragraph

Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiyu LiuJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.ORCID https://orcid.org/0009-0002-5224-1714

Haolin LiJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.ORCID https://orcid.org/0009-0006-3190-0441

Yu DaiJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.ORCID https://orcid.org/0009-0002-8647-3222

Jingyi NiuJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.ORCID https://orcid.org/0009-0002-1849-0346

Linhan JiangJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.ORCID https://orcid.org/0009-0001-2076-947X

Jia TangJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.ORCID https://orcid.org/0009-0007-1291-1329

Rendong FangJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.ORCID https://orcid.org/0000-0003-3094-5059

Chao YeJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.ORCID https://orcid.org/0000-0001-6255-9684

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudorabies (PR) virus (PRV), also known as suid herpesvirus 1, is an alphaherpesvirus that causes huge economic losses in the global swine industry. Necroptosis, a caspase-independent programmed cell death, has been demonstrated to play an important role in regulating viral infections. Here, we showed that PRV infection triggered receptor-interacting protein (RIP) kinase (RIPK) 3/mixed lineage kinasedomain-like (MLKL)-dependent necroptosis in BV2 microglial cells. Mechanistically, PRV infection induced the formation of

Indexed as

Herpesvirus 1, SuidMicrogliaNecroptosisProtein KinasesPseudorabiesReceptor-Interacting Protein Serine-Threonine KinasesRNA-Binding ProteinsAnimalsCell LineMiceMLKL protein, mouseProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRipk3 protein, mouseRNA-Binding ProteinsZbp1 protein, mousemixed lineage kinase domain-likenecroptosispseudorabies virusreceptor-interacting protein kinase 3Z-nucleic acid-binding protein 1

Identifiers

PMID41098523

DOI10.1155/tbed/8510846

PMCPMC12520810

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.