Evidence map›Paper›PMID 41098669›Full record

SynthesisRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2025

Gestational weight gain according to treatment in gestational diabetes: a systematic review and meta-analysis.

Carolina de Freitas Alves Amaral-Moreira, Daiane Sofia de Morais Paulino, José Paulo Siqueira Guida, Belmiro Gonçalves Pereira, Patrícia Moretti Rehder, Fernanda Garanhani Surita

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carolina de Freitas Alves Amaral-MoreiraUniversidade Estadual de Campinas Faculdade de Ciências Médicas CampinasSP Brazil Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP Brazil.ORCID https://orcid.org/0000-0001-6741-1232
Daiane Sofia de Morais PaulinoUniversidade Estadual de Campinas Faculdade de Ciências Médicas CampinasSP Brazil Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP Brazil.ORCID https://orcid.org/0000-0002-6365-5608
José Paulo Siqueira GuidaUniversidade Estadual de Campinas Faculdade de Ciências Médicas CampinasSP Brazil Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP Brazil.ORCID https://orcid.org/0000-0002-3648-6159
Belmiro Gonçalves PereiraUniversidade Estadual de Campinas Faculdade de Ciências Médicas CampinasSP Brazil Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP Brazil.ORCID https://orcid.org/0000-0002-6209-6189
Patrícia Moretti RehderUniversidade Estadual de Campinas Faculdade de Ciências Médicas CampinasSP Brazil Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP Brazil.ORCID https://orcid.org/0000-0003-4530-1109
Fernanda Garanhani SuritaUniversidade Estadual de Campinas Faculdade de Ciências Médicas CampinasSP Brazil Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP Brazil.ORCID https://orcid.org/0000-0003-4335-0337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: In this systematic review, we aim to compare the GWG in pregnant women with diabetes treated with metformin and other interventions. Methods: Data Sources: The searched baselines included PubMed, Scopus, Web of Science, Embase, and Virtual Health Library (BVS). Study selection: We selected articles that compared the GWG in women with diabetes treated with metformin or insulin. We have included clinical trials (randomized or not), observational studies (cohort, case control, and cross-sectional). Reviews (systematic or not), posters, event abstracts, and letters were excluded. Data Collection: We pooled odds ratios (OR) and mean difference (MD) and used a random effect model using R Studio software to compare the weight gain, fetal birthweight and preeclampsia according to treatment. Results: On research conducted in January 2024, with no data limit of the search, 433 trials were identified, of which 175 remained after duplicate removal. 50 studies were analyzed in the full text analyses and 9 were selected for the systematic review. 8 studies demonstrated that gestational weight gain during metformin treatment is lower when compared to other treatments, especially insulin, although it was not different from other outcomes. Meta-analyses demonstrated that oral medication GWG is lower than insulin with a standard mean difference (SMD) -1,05 [-1,87, - 0,23]. Conclusion: Oral medication has a lower gestational weight gain in patients with gestational diabetes when compared to insulin. International Prospective register of Systematic Reviews PROSPERO: CRD 42024492158.

Indexed as

Diabetes, GestationalGestational Weight GainHypoglycemic AgentsMetforminFemaleHumansInsulinPregnancyHypoglycemic AgentsInsulinMetforminGestational diabetesGestational weight gainInsulinMetformin

Identifiers

PMID41098669
PMCPMC12520727

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.