Evidence map›Paper›PMID 41099151›Full record

ArticleHuman vaccines & immunotherapeutics2025

Cancer-testis antigen ACRBP: Cytotoxic response to its HLA-A2 restricted peptide and immune features in ovarian cancer.

Xia Zeng, Li-Na Lin, Xiaoquan Li, Wei-Xia Nong, Feng Li, Li Lan, Ping Wang, Ai Ye, Qing-Mei Zhang, Bin Luo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xia ZengDepartment of Immunology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Li-Na LinDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P. R. China.
Xiaoquan LiDepartment of Immunology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Wei-Xia NongDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Feng LiDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Li LanDepartment of Immunology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Ping WangDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Ai YeDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Qing-Mei ZhangDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Bin LuoDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Ying-Ying GeDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.
Xiao-Xun XieDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While our prior study identified the HLA-A *0201-restricted ACRBP epitope peptide and demonstrated its capacity to generate cytotoxic T lymphocytes (CTLs) in vitro, the clinical relevance of the peptide-induced T cell reactivity in ovarian cancer (OC) patients and the in vivo anti-tumor efficacy of these CTLs remain unexplored. In this study, dendritic cells were sensitized with ACRBP peptide (ALLVLCYSI) and co-cultured with autologous CD8

Indexed as

Antigens, NeoplasmHLA-A2 AntigenOvarian NeoplasmsT-Lymphocytes, CytotoxicAnimalsCD8-Positive T-LymphocytesCell Line, TumorCoculture TechniquesDendritic CellsDisease Models, AnimalFemaleHumansMiceMice, SCIDAntigens, NeoplasmHLA-A2 AntigenACRBPCancer-testis antigenCTLovarian cancer

Identifiers

PMID41099151
PMCPMC12533956

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.